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The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer
(Impact Journals LLC, 2017)
Chemoresistance is one of the major hurdles in the treatment of breast cancer, which limits the effect of both targeted and conventional therapies in clinical settings. Therefore, understanding the mechanisms underpinning ...
The emerging role of long non-coding RNA in gallbladder cancer pathogenesis
(Elsevier B.V., 2017)
Gallbladder cancer (GBC) is the most common and aggressive form of biliary tract carcinoma with an alarmingly low 5-year survival rate. Despite its high mortality rate, the underlying mechanisms of GBC pathogenesis are not ...
Role of sphingosine-1-phosphate in mast cell functions and asthma and its regulation by non-coding RNA
(Frontiers Media S.A., 2017)
Sphingolipid metabolites are emerging as important signaling molecules in allergic diseases specifically asthma. One of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), is involved in cell differentiation, ...
Atypical leishmaniasis: A global perspective with emphasis on the Indian subcontinent
(Public Library of Science, 2018)
Background: Among the neglected tropical diseases, leishmaniasis continues to be prevalent in many tropical and subtropical countries despite international, national, and local efforts towards its control and elimination ...
An intraspecies Leishmania donovani hybrid from the Indian subcontinent is associated with an atypical phenotype of cutaneous disease
(Elsevier Inc., 2022-01-22)
Leishmaniasis is a neglected tropical disease endemic in over 90 countries. The disease has two main pathologies; cutaneous leishmaniasis (CL) that generally self-heals, and visceral leishmaniasis (VL) that is fatal if ...
An Insight Into Systemic Immune Response in Leishmania donovani Mediated Atypical Cutaneous Leishmaniasis in the New Endemic State of Himachal Pradesh, India
(Frontiers Media S.A., 2022-01-04)
Leishmaniasis continues to afflict known and newer endemic sites despite global efforts towards its control and elimination. In this regard, the emergence of newer endemic sites with unusual disease formats is recognized ...
Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms
(Taylor and Francis Ltd., 2021-04-19)
Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their ...