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Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement
(Academic Press, 2020)
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid that has the potential to affect human ...
Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
(Neoplasia Press, Inc., 2020)
Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer ...
Anti-cancer drug doxorubicin induced cardiotoxicity: Understanding the mechanisms involved in ros generation resulting in mitochondrial dysfunction
(Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma, 2020)
Doxorubicin (DOX), despite being an effective anti-cancer drug has offsite targets that affect the vital organs such as heart, brain and kidney. DOX-induced cardiotoxicity is reported as a multi-factorial process that ...
Circulating microRNA-590-5p functions as a liquid biopsy marker in non-small cell lung cancer
(Blackwell Publishing Ltd, 2020)
Despite the availability of various diagnostic procedures, a tissue biopsy is still indispensable for the routine diagnosis of lung cancer. However, inaccurate diagnoses can occur, leading to inefficient cancer management. ...
Phytochemical ginkgolide b protects cultured neuroblastoma SH-SY5Y cells against a?(25-35) induced oxidative stress responses by maintaining the mitochondrial integrity
(Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma, 2020)
Alzheimer�s disease is associated with oxidative stress induced by accumulation of A? peptide, by disrupting the mitochondrial function. In this study, the oxidative stress responses induced by A?(25-35) and protective ...
Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes
(Elsevier, 2020)
Ethnopharmacological relevance: Doxorubicin (DOX) is an effective anti-neoplastic drug, however; it has downside effects on cardiac health and other vital organs. The herbal remedies used in day to day life may have a ...