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Role of Macromolecular Crowding on Stability and Iron Release Kinetics of Serum Transferrin
(American Chemical Society, 2017)
The macromolecular crowding influences the structural stability and functional properties of transferrin (Tf). The equilibrium as well as kinetic studies of Tf at different concentrations of crowding agents (dextran 40, ...
Macromolecular crowding-induced molten globule states of the alkali pH-denatured proteins
(Elsevier B.V., 2018)
Structural and molecular properties extracted from circular dichroism (CD), tryptophan fluorescence and 1-anilino-8-napthalene sulfonate (ANS) binding experiments suggest that the high concentration of synthetic crowding ...
Factors defining the effects of macromolecular crowding on dynamics and thermodynamic stability of heme proteins in-vitro,
(Elsevier, 2018)
The role of crowding agents on structure and activities of heme proteins has been established. Analysis of kinetic and thermodynamic parameters measured for CO-dissociation reaction of natively-folded carbonmonoxycytochrome ...
Single-molecule force-unfolding of titin I27 reveals a correlation between the size of the surrounding anions and its mechanical stability
(Royal Societty of chemistry, 2018)
Each cellular protein is surrounded by a biochemical milieu that affects its stability and the associated function. The role of this surrounding milieu in the proteins’ mechanical stability remains largely unexplored. ...
Macromolecular crowding on Dynamics and Thermodynamic Stability of Heme Proteins
(Elsevier, 2018)
Structural and molecular properties extracted from circular dichroism (CD), tryptophanfluorescence and 1-anilino-8-napthalene sulfonate (ANS) binding experiments suggest that the high concentration of synthetic crowding ...
Factors Defining the Effects of macromolecularcrowding on dynamics and thermodynamics stability of heme proteins in-vitro
(Elsevier, 2018)
The role of crowding agents on structure and activities of heme proteins has been established. Analysis of kinetic and thermodynamic parameters measured for CO-dissociation reaction of natively-folded carbonmonoxycytochrome ...
Single-molecule analysis of osmolyte-mediated nanomechanical unfolding behavior of a protein domain
(Elsevier B.V., 2023-09-16)
The small organic molecules, known as osmolytes being ubiquitously present in different cell types, affect protein folding, stability and aggregation. However, it is unknown how the osmolytes affect the nanomechanical ...
Substitution of carbonate by non-physiological synergistic anion modulates the stability and iron release kinetics of serum transferrin
(Elsevier B.V., 2022-10-15)
Serum transferrin (sTf) is a bi-lobal protein. Each lobe of sTf binds one Fe3+ ion in the presence of a synergistic anion. Physiologically, carbonate is the main synergistic anion but other anions such as oxalate, malonate, ...
Analysis of the effect of 1-Allyl-3-Methylimidazolium chloride on thermodynamic stability, folding kinetics, and motional dynamics of horse cytochrome c
(Elsevier B.V., 2022-09-08)
1-allyl-3-methylimidazolium chloride (AMIMCl) acts as a potential green solvent for proteins. The present work provides a possible pathway by which the structural, kinetic, thermodynamic, and folding properties of horse ...