Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Title
Now showing items 20-39 of 272
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C-N and N-N bond formation via reductive cyclization: Progress in cadogan/cadogan-sundberg reaction
(Wiley-Blackwell, 2018)Cadogan/Cadogan-Sundberg cyclization reaction has been reported as one of the most efficient routes for the synthesis of a wide variety of N-heterocycles from the easily accessible starting materials such as o-nitrobiaryls ... -
C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors
(ACS Publications, 2015)Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors. However, there is substantial interest in its activities at the ... -
Carbon-Based Fluorescent Nano-Biosensors for the Detection of Cell-Free Circulating MicroRNAs
(MDPI, 2023-02-06)Currently, non-communicable diseases (NCDs) have emerged as potential risks for humans due to adopting a sedentary lifestyle and inaccurate diagnoses. The early detection of NCDs using point-of-care technologies significantly ... -
Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles
(2012)Silver nanoparticles (Ag NPs) are used in consumer products and wound dressings due to their antimicrobial properties. However, in addition to toxic effects on microbes, Ag NPs can also induce stress responses as well as ... -
Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022
(American Chemical Society, 2023-07-26)Serine/threonine-protein kinase B-Raf (BRAF; RAF = rapidly accelerated fibrosarcoma) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade. Somatic mutations in the BRAF gene were first ... -
Chemical Composition and Biological Activity of Essential Oils from Wild Growing Aromatic Plant Species of Skimmia laureola and Juniperusmacropoda from Western Himalaya
(NPC (Natural Product Communication), 2015)The Himalayan region is very rich in a great variety of medicinal plants. In this investigation the essential oils of two selected species are described for their antimicrobial and larvicidal as well as biting deterrent ... -
Chemical composition and biological activity of essential oils of dracocephalum heterophyllum and hyssopus officinalis from western himalaya
(Natural Product Incorporation, 2015)The essential oils of two representatives of the Lamiaceae, Dracocephalum heterophyllum Benth. And Hyssopus officinalis L., are described for their antifungal, antibacterial, larvicidal and inect biting deterrent activities. ... -
Chemical composition and biological activity of essential oils of dracocephalum heterophyllum benth And Hyssopus officinalis L Collected wild from Western Himalay
(Sage, 2015)The essential oils of two representatives of the Lamiaceae, Dracocephalum heterophyllum Benth. and Hyssopus officinalis L., are described for their antifungal, antibacterial, larvicidal and inect biting deterrent activities. ... -
Chemical composition and biological effects of Artemisia essential oils from Western Himalaya
(Theime, 2014)Artemisia species possess pharmacological properties that are used for medical purposes worldwide. In this paper, the essential oils from the aerial parts of Artemisia nilagirica and Artemisia maritima from the western ... -
Chemical composition and biological effects of artemisia maritima and artemisia nilagirica essential oils from wild plants of Western Himalaya
(Georg Thieme Verlag, 2014)Artemisia species possess pharmacological properties that are used for medical purposes worldwide. In this paper, the essential oils from the aerial parts of Artemisia nilagirica and Artemisia maritima from the western ... -
Chitosan-supported copper as an efficient and recyclable heterogeneous catalyst for A3/decarboxylative A3-coupling reaction
(Elsevier Ltd, 2018)Chitosan-supported copper (chit@copper) based heterogeneous catalysts have been explored for A3-coupling and decarboxylative A3-coupling. The developed protocol employs low catalyst loading, solventless condition and easy ... -
Compendium of naringenin: potential sources, analytical aspects, chemistry, nutraceutical potentials and pharmacological profile
(Taylor and Francis Ltd., 2022-03-31)Naringenin is flavorless, water insoluble active principle belonging to flavanone subclass. It exhibits a diverse pharmacological profile as well as divine nutraceutical values. Although several researchers have explored ... -
A comprehensive review on bioactive fused heterocycles as purine-utilizing enzymes inhibitors
(Birkhauser Boston, 2015)Purine-utilizing enzymes (PUEs) are involved in the control of biological actions of nitrogen-containing bases, purines and pyrimidines, by participating in their catabolism, and this has made them a topic of considerate ... -
Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives
(Elsevier Ltd, 2016)The metabotropic glutamate receptors (mGlu receptors) have emerged as attractive targets for number of neurological and psychiatric disorders. Recently, mGluR5 negative allosteric modulators (NAMs) have gained considerable ... -
Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
(MDPI, 2022-08-30)Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves ... -
The Concept of Receptor and Molecule Interaction in Drug Discovery and Development
(Springer Singapore, 2021-02-18)The mechanisms by which drugs act are different and unique to each class as they involve interactions with pharmacological receptors, enzymes, ion channels, and cellular transport processes. Hormones, neurotransmitters, ... -
Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review
(NLM (Medline), 2018)BACKGROUND: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug ... -
Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.
(Bentham Science, 2018)Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug ... -
Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
(Elsevier Masson SAS, 2015)Abstract Coumarins are fused benzene and pyrone ring systems which prompt biological investigation to assess their potential therapeutic significance. It possesses immeasurable anticancer potential with minimum side effects ... -
Cucumis melo Var. agrestis Naudin as a potent antidiabetic: Investigation via experimental methods
(Elsevier B.V., 2022-09-06)Background: The present study reveals that the ethanolic extract of Cucumis melo var. agrestis (CMVA), can influence the activity of blood glucose level, insulin level, oxidative stress, and lipid profile in Alloxan ...