Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Title
Now showing items 82-101 of 272
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FDA approved five-membered ring fused pyrimidine-based derivatives and their biological properties
(Elsevier, 2022-10-14)Pyrimidines-based drugs are one of the most important drugs for novel and recurring viruses, including the coronavirus. This chapter deals with 41 FDA-approved five-membered ring fused pyrimidine-based drugs, their synthetic ... -
FDA approved fused pyrimidine-based drugs
(Elsevier, 2022-10-14)The present chapter is a compilation and analysis of USFDA approved small drug candidates about fused pyrimidine pharmacophore. Out of 63 drugs approved so far, nearly 38% of drugs are approved for chemotherapeutic treatment ... -
FDA approved six-membered ring fused pyrimidine-based derivatives
(Elsevier, 2022-10-14)Pyrimidine-based derivatives play a vital role in the development of drugs due to their indispensable role in various biological processes. To date, ring fused pyrimidine-based derivatives have been reported to exhibit ... -
Flavonoids as P-glycoprotein inhibitors for multidrug resistance in cancer: an in-silico approach
(Taylor and Francis Ltd., 2022-09-19)Cancer has become a leading cause of mortality due to non-communicable diseases after cardiovascular disease worldwide and is increasing day by day at a daunting pace. According to an estimate by 2040 there will be 28.4 ... -
Flavonoids as promising anticancer agents: an in silico investigation of ADMET, binding affinity by molecular docking and molecular dynamics simulations
(Taylor and Francis Ltd., 2022-09-27)Cancer is one of the most concerning diseases to humankind. Various treatment strategies are being employed for its treatment, out of which use of natural products is an essential one. Flavonoids have proven to be promising ... -
Fused Pyrimidine-Based Drug Discovery
(Elsevier, 2022-10-14)Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers the chemistry and biological activities, as well as the design of novel ... -
Gaussian field-based 3D-QSAR and molecular simulation studies to design potent pyrimidine-sulfonamide hybrids as selective BRAFV600E inhibitors
(Royal Society of Chemistry, 2022-10-21)The �RAS-RAF-MEK-ERK� pathway is an important signaling pathway in melanoma. BRAFV600E (70-90%) is the most common mutation in this pathway. BRAF inhibitors have four types of conformers: type I (?C-IN/DFG-IN), type II ... -
Gaussian field-based comparative 3D QSAR modelling for the identification of favourable pharmacophoric features of chromene derivatives as selective inhibitors of ALR2 over ALR1
(Springer, 2021-01-07)Aldehyde reductase (ALR1) and aldose reductase (ALR2) are both oxo-reductase enzymes of aldo-keto reductase (AKR) superfamily involved in several cellular processes. ALR1 plays an important role in colorectal cancer, lungs, ... -
Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study
(Elsevier Ltd, 2016)Vitamin D deficiency is implicated in multiple disease conditions and accumulating evidence supports that the variation in serum vitamin D (25(OH)D) levels, including deficiency, is under strong genetic control. However, ... -
Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab
(Springer, 2019)Human epidermal growth factor receptor 2 positive (HER2+) breast cancer (BC) is an aggressive BC subtype characterized by HER2 overexpression/amplification. Genomic alterations of HER2 and others have been reported to be ... -
Global trends in pesticides: A looming threat and viable alternatives
(Academic Press, 2020)Pesticides are widely used chemical compounds in agriculture to destroy insects, pests and weeds. In modern era, they form an indispensable part of agricultural and health practices. Globally, nearly 3 billion kg of ... -
Glycine Catalyzed One-Pot Three-Component Synthesis of Structurally Diverse 2-Amino Substituted Pyran Annulated Heterocycles in Aqueous Ethanol under Refluxed Conditions
(Bentham Science Publishers, 2022-12-14)Introduction: A facile, convenient and general method has been developed for the one-pot three-component synthesis of structurally diverse 2-amino pyran annulated heterocycles from the reactions of aromatic aldehydes, ... -
Growth factors mediated cell signalling in prostate cancer progression: Implications in discovery of anti-prostate cancer agents.
(Elsevier, 2015)Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer is one of the most encountered malignancies among men. Globally, it is the sixth leading cause of cancer-related death ... -
Herbal anthelmintic agents: a narrative review
(Journal of Traditional Chinese Medicine, 2022-08-02)Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases, considered as neglected tropical diseases (NTDs) that infect around two billion people worldwide. Plants have been used as anthelmintics ... -
Hetero Cyclic Compounds in the Treatment of Triple-Negative Breast Cancer
(Bentham Science Publishers, 2023-01-02)Triple-negative breast cancer (TNBC) holds just about 15% of all breast tumours and sub-types of breast cancer with distinct characteristics of negative expressions for the progesterone recep-tor, estrogen receptor, and ... -
Historical Perspective of Drug Discovery and Development
(Springer Singapore, 2021-02-18)Historically ever since the existence of humans on this planet the process of drug discovery was started by trial and error method. Initially they tested the natural products on self to understand the effects. Serendipity ... -
Identification of 1,3,4-oxadiazoles as tubulin-targeted anticancer agents: a combined field-based 3D-QSAR, pharmacophore model-based virtual screening, molecular docking, molecular dynamics simulation, and density functional theory calculation approach
(Taylor and Francis Ltd., 2023-09-11)Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial protein of cytoskeleton that maintains essential cellular functions including cell division as well as cell signalling, that makes an ... -
Identification of new insulin growth factor receptor-1 (IGF-1R) inhibitors via exploring ATPas kinase domain of IGF-1R through virtual screening
(Birkhauser Boston, 2017)Insulin growth factor receptor-1 is a trans-membrane tyrosine kinase receptor that mediates the polypeptide protein hormone insulin growth factor-1, responsible for normal function and growth of human cells. The overexpression ... -
Identification of novel indole based heterocycles as selective estrogen receptor modulator
(Academic Press Inc., 2018)In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ... -
Identification of novel indole based heterocycles as selective estrogen receptor modulator.
(Elsevier, 2018)In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ...