Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Title
Now showing items 124-143 of 272
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Knoevenagel/tandem knoevenagel and michael adducts of cyclohexane-1,3-dione and aryl aldehydes: Synthesis, DFT studies, xanthine oxidase inhibitory potential, and molecular modeling
(American Chemical Society, 2019)Xanthine oxidase (XO) plays a crucial role in the formation of uric acid by oxidative hydroxylation of purines. Herein, we report the design and synthesis of Knoevenagel/tandem Knoevenagel and Michael adducts of ... -
Mandelic acid catalyzed one-pot pseudo three-component synthesis of various trisubstituted methane derivatives at room temperature
(Arkat, 2022-11-03)A simple, mild, eco-friendly, general and convenient approach has been developed for the synthesis of various trisubstituted methane derivatives via one-pot pseudo three-component reactions between one equivalent of aromatic ... -
Mannose conjugated starch nanoparticles for preferential targeting of liver cancer
(Bentham Science Publishers, 2020-09-04)Aim: To design D-Mannose conjugated 5-Fluorouracil (5-FU) loaded Jackfruit seed starch nanoparticles (JFSSNPs) for site-specific delivery. Background: Liver cancer is the third leading cause of death in the world and the ... -
Mechanisms of tubulin binding ligands to target cancer cells: Updates on their therapeutic potential and clinical trials
(Bentham Science Publishers B.V., 2017)Background: A number of chemically diverse substances bind to the tubulin and inhibit cell proliferation by disrupting microtubule dynamics. There are four binding sites for the ligands binding to the tubulin; taxane/epothilone ... -
Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review
(2013)Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble purines which prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial ... -
Medicinal chemistry aspects and synthetic strategies of coumarin as aromatase inhibitors: an overview
(Springer, 2022-12-05)Coumarin is a bicyclic oxygen bearing heterocyclic scaffold formed by fusion of benzene with the pyrone ring. Because of its unique physicochemical characteristics and the ease with which it may be transformed into a wide ... -
Medicinal Chemistry Aspects of Isoxazole Analogues as Anti-tubercular Agents
(Bentham Science Publishers, 2023-10-11)Tuberculosis (TB) is the major cause of mortality around the world and one of the most common diseases linked to AIDS. Due to the emergence of multi-drug resistance, extensive drug resistance, and total drug resistance ... -
Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
(Royal Society of Chemistry, 2023-03-03)Cancer is a major cause of deaths across the globe due to chemoresistance and lack of selective chemotherapy. Pyrido[2,3-d]pyrimidine is an emerging scaffold in medicinal chemistry having a broad spectrum of activities, ... -
The medicinal perspective of 2,4-thiazolidinediones based ligands as antimicrobial, antitumor and antidiabetic agents: A review
(John Wiley and Sons Inc, 2022-06-18)2,4-Thiazolidinedione (2,4-TZD), commonly known as glitazone, is a ubiquitous heterocyclic pharmacophore possessing a plethora of pharmacological activities and offering a vast opportunity for structural modification. The ... -
MEK inhibitors in cancer treatment: structural insights, regulation, recent advances and future perspectives
(Royal Society of Chemistry, 2023-08-10)MEK1/2 are critical components of the RAS-RAF-MEK-ERK or MAPK signalling pathway that regulates a variety of cellular functions including proliferation, survival, and differentiation. In 1997, a lung cancer cell line was ... -
Melphalan: Recent insights on synthetic, analytical and medicinal aspects
(Elsevier Masson s.r.l., 2022-05-27)Cancer is an uncontrolled expansion of atypical cells in the body. These unusual cells are labelled as cancerous or malignant cells. Melphalan, an anticancer drug which is imperatively recognized under the class of alkylating ... -
Metal Complexes in Cancer Treatment: Journey So Far
(John Wiley and Sons Inc, 2023-02-24)Metal complexes in cancer therapy have attracted much interest mainly because metals exhibit unique characteristics, such as redox activity, metal-ligand interaction, structure and bonding, Lewis acid properties etc. In ... -
Metal- And Solvent-Free Multicomponent Decarboxylative A3-Coupling for the Synthesis of Propargylamines: Experimental, Computational, and Biological Investigations
(American Chemical Society, 2020)Decarboxylative A3-coupling of ortho-hydroxybenzaldehydes, secondary amines, and alkynoic acids is performed under catalyst and solvent-free conditions. The developed methodology provided a waste-free method for the synthesis ... -
Microsponges as Drug Delivery System: Past, Present, and Future Perspectives
(Bentham Science Publishers, 2023-04-04)Microsponges are polymeric delivery devices composed of porous microspheres that range in size from 5 to 300 micrometers. These have been explored for biomedical applications such as targeted drug deliv-ery, transdermal ... -
Microwave-assis synthesis of pyrazolo[1,5c] quinazolines and their derivatives
(Elsevier, 2014)Microwave accelerated and expedited cyclocondensation reactions of 2-(3-aryl-1H-pyrazol-5-yl)anilines (4) with diverse aryl aldehydes/triethyl orthoformate in water/MeCN (route D) and internal cyclocondensation and ... -
Microwave-assisted synthesis of pyrazolo[1,5-c]quinazolines and their derivatives
(Elsevier, 2014)Microwave accelerated and expedited cyclocondensation reactions of 2-(3-aryl-1H-pyrazol-5-yl)anilines (4) with diverse aryl aldehydes/triethyl orthoformate in water/MeCN (route D) and internal cyclocondensation and ... -
A Minireview on the Scope of Cadogan Cyclization Reactions Leading to Diverse Azaheterocycles
(John Wiley and Sons Inc, 2022-04-01)From the last two decades, Cadogan cyclization reaction is considered as one of the best routes for the preparation of various azaheterocycles comprising carbazoles, indoles, coumarins, carbolines, pyrazoloquinoxalines, ... -
Molecular Docking and In Vitro Anticancer Screening of Synthesized Arylthiazole linked 2H-indol-2-one Derivatives as VEGFR-2 Kinase Inhibitors
(Bentham Science Publishers, 2021-11-18)Background: Indoline-2,3-dione comprises a leading course group of heterocycles endowed with appealing biological actions, including anticancer activity. There are significant justifications for exploring the anticancer ... -
Molecular docking simulation study of phytoestrogens asparagus racemosus in breast cancer progression
(International Journal Of Pharmaceutical Sciences And Research (IJPSR), 2015)Phytoestrogens are the xenoestrogens which are derived from the plant. This is the first report providing the deeper inside into the mechanism involved in restricting breast cancer progression with the help of docking ... -
Molecular docking study of natural alkaloids as multi-targeted hedgehog pathway inhibitors in cancer stem cell therapy.
(Elsevier, 2015)Cancer is responsible for millions of deaths throughout the world every year. Increased understanding as well as advancements in the therapeutic aspect seems suboptimal to restrict the huge deaths associated with cancer. ...