Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Title
Now showing items 186-205 of 272
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Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling
(Academic Press, 2015)Despite the fact that radiation therapy is a highly effective therapeutic approach, a small intratumoral cell subpopulation known as "cancer stem cells" (CSCs) is radiation-resistant and possesses specific molecular ... -
Rational design and synthesis of novel biphenyl thiazolidinedione conjugates as inhibitors of protein tyrosine phosphatase 1B for the management of type 2 diabetes
(Elsevier B.V., 2022-11-12)To achieve the unmet discovery of protein tyrosine phosphatase 1B (PTP1B) inhibitors, we have rationally designed novel biphenyl thiazolidinedione conjugates (8a-n). The designed molecules were found fit on in silico ... -
Rationalization of the activity Profile of Pyruvate Kinase Isozyme M2 (PKM2) Inhibitors using 3D QSAR
(Bentham Science Publishers, 2021-08-05)Introduction: Pyruvate kinase isozyme M2 (PKM2) was observed to be overexpressed and play a key role in cell growth and cancer cells' metabolism. During the past years, phytochemicals have been developed as new treatment ... -
Recent Advancement of Polymersomes as Drug Delivery Carrier
(Bentham Science Publishers, 2022-04-14)Background: Biomedical applications of polymersomes have been explored, including drug and gene delivery, insulin delivery, hemoglobin delivery, the delivery of anticancer agents, and various diagnostic purposes. Objectives: ... -
Recent advancements in mechanistic studies and structure activity relationship of FoF1 ATP synthase inhibitor as antimicrobial agent
(Elsevier Masson SAS, 2019)The emergence of drug resistance in infectious microbial strains can be overcome by development of novel drug molecules against unexploited microbial target. The success of Bedaquiline in recent years, as FoF1 ATP synthase ... -
Recent advancements in small molecule inhibitors of insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase as anticancer agents
(2013)Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer in human, have driven the current cancer chemotherapy to intently focus on development of target-based approaches rather ... -
Recent Advancements in Small Molecule Inhibitors of Insulin–like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase as Anticancer agents
(Bentham Science, 2013)Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer in human, have driven the current cancer chemotherapy to intently focus on development of target-based approaches rather ... -
Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer
(Bentham Science Publishers, 2022-11-16)Discovery of MDM2 and MDM2-p53 interaction inhibitors changed the direction of anticancer research as it is involved in about 50% of cancer cases globally. Not on-ly the inhibition of MDM2 but also its interaction with p53 ... -
Recent advances in decarboxylative C-C bond formation using direct or in situ generated alkenyl acids
(Taylor and Francis Inc., 2019)In recent years, the reactions of abundantly available, inexpensive, and structurally diverse alkenyl acids (-C=C-COOH) with C-X (X = halogen) or C-H coupling partner have emerged as vital strategies for the streamlined ... -
Recent Advances in Plant Metabolites Analysis, Isolation, and Characterization
(Springer, 2018)Metabolites from natural sources either from terrestrial or marine sources serve as unmatched resources for new drug leads or diverse chemical identity. Due to ever-rising requirement for new pharmacophore in high-throughput ... -
Recent development in indole derivatives as anticancer agent: A mechanistic approach
(Bentham Science Publishers, 2021-01-05)Background: Cancer accounts for several deaths each year. There are multiple FDA approved drugs for cancer treatments. Due to the severe side effects and multiple drug resistance, the current drug therapies become ineffective. ... -
Recent development in indole derivatives as anticancer agents for breast cancer
(Bentham Science Publishers, 2019)Background: Breast Cancer (BC) is the second most common cause of cancer related deaths in women. Due to severe side effects and multidrug resistance, current therapies like hormonal therapy, surgery, radiotherapy and ... -
Recent Developments in Oxazole Derivatives as Anticancer Agents: Review on Synthetic Strategies, Mechanism of Action and SAR Studies
(Bentham Science Publishers, 2021-09-16)Background: Cancer is the world�s third deadliest disease. Despite the availability of numerous treatments, researchers are focusing on the development of new drugs with no resistance and toxicity issues. Many newly ... -
Recent developments of C-4 substituted coumarin derivatives as anticancer agents
(Elsevier Masson SAS, 2016)Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand ... -
Recent developments on 1,2,4-triazole nucleus in anticancer compounds: A review
(Bentham Science Publishers B.V., 2016)1,2,4 triazole is an important nucleus present in a large number of compounds. More than thirty-five compounds containing this nucleus are introduced into the market. 1,2,4-triazole nucleus is stable to metabolism and acts ... -
Recent efforts for drug identification from phytochemicals against SARS-CoV-2: Exploration of the chemical space to identify druggable leads
(Elsevier Ltd, 2021-04-03)Nature, which remains a central drug discovery pool, is always looked upon to find a putative druggable lead. The natural products and phytochemical derived from plants are essential during a global health crisis. This ... -
Recent insights into the hepatoprotective potential of medicinal plants and plant-derived compounds
(John Wiley and Sons Ltd, 2023-04-06)Liver problems are a worldwide concern, and conventional medicinal therapies are ineffective. Hence, safeguarding the healthy liver is vital for good health and well-being. Infections due to virus, immune problems, cancer, ... -
Recent trends in anticancer drug development: Challenges and opportunities
(Bentham Science Publishers B.V., 2017)[No abstract available] -
Reconnoitering the transformative journey of minocycline from an antibiotic to an antiepileptic drug
(Elsevier Inc., 2022-01-20)Minocycline, a second-generation tetracycline antibiotic is being widely tested in animals as well as clinical settings for the management of multiple neurological disorders. The drug has shown to exert protective action ... -
Regioselective alkylation of 1,2,4-triazole using ionic liquids under microwave conditions
(Walter de Gruyter GmbH, 2016)1-Substituted 1,2,4-triazole derivatives present in a large number of compounds and display a variety of bioactivities such as antibiotic, anti-inflammatory, anti-diabetic, antipsychotic, and anticancer. A regioselective ...