Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Submit Date
Now showing items 21-40 of 272
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Impact of ABC transporters, glutathione conjugates in MDR and their modulation by flavonoids: An overview
(2014)Overexpression of ATP-binding cassette (ABC) transporter and glutathione conjugates results in efflux of cytotoxic agent from tumor cells leading to multidrug resistance (MDR). Many MDR inhibitors have been identified but ... -
Interaction model of steviol glycosides from Stevia rebaudiana (Bertoni) with sweet taste receptors: A computational approach
(Elsevier Ltd, 2015)Docking studies were performed on natural sweeteners from Stevia rebaudiana by constructing homology models of T1R2 and T1R3 subunits of human sweet taste receptors. Ramachandran plot, PROCHECK results and ERRAT overall ... -
Chemical composition and biological effects of artemisia maritima and artemisia nilagirica essential oils from wild plants of Western Himalaya
(Georg Thieme Verlag, 2014)Artemisia species possess pharmacological properties that are used for medical purposes worldwide. In this paper, the essential oils from the aerial parts of Artemisia nilagirica and Artemisia maritima from the western ... -
Molecular docking simulation study of phytoestrogens asparagus racemosus in breast cancer progression
(International Journal Of Pharmaceutical Sciences And Research (IJPSR), 2015)Phytoestrogens are the xenoestrogens which are derived from the plant. This is the first report providing the deeper inside into the mechanism involved in restricting breast cancer progression with the help of docking ... -
Chemical Composition and Biological Activity of Essential Oils from Wild Growing Aromatic Plant Species of Skimmia laureola and Juniperusmacropoda from Western Himalaya
(NPC (Natural Product Communication), 2015)The Himalayan region is very rich in a great variety of medicinal plants. In this investigation the essential oils of two selected species are described for their antimicrobial and larvicidal as well as biting deterrent ... -
Photoprotective, antioxidant screening and new ester from dry root extracts of Potentilla atrosanguinea (Himalayan cinquefoil)
(Elsevier, 2016)In vitro photoprotective and antioxidant activities of dried aqueous-methanolic (H2O/MeOH) crude extract and ethyl acetate (EtOAc), n-butanol (n-BuOH) as well as aqueous (H2O) fractions of roots of western Himalayan plant ... -
Synthesis of rebaudioside A from stevioside and their interaction model with hTAS2R4 bitter taste receptor
(Elsevier Ltd, 2016)Steviol glycosides (SG's) from Stevia rebaudiana (Bertoni) have been used as a natural low-calorie sweeteners. Its aftertaste bitterness restricts its use for human consumption and limits its application in food and ... -
An in-silico approach on essential oil molecules as apoptosis inducer in cancer chemotherapy
(Innovations in Pharmaceuticals and Pharmacotherapy, 2017)Essential oils (EOs) are very engrossing natural plant products and apart from this they possess various biological properties. It has been reported that these essential oil molecules are able to inhibit tumor cell ... -
Antimicrobial and repellent activity of the essential oils of two lamiaceae cultivated in Western Himalaya
(Bentham Science Publishers B.V., 2015)The essential oils of two Lamiaceae cultivated in Western Himalaya were examined on their antimicrobial, biting deterrent as well as larvicidal activity. Additionally their odors are described and their chemical compositions ... -
Recent Advancements in Small Molecule Inhibitors of Insulin–like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase as Anticancer agents
(Bentham Science, 2013)Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer in human, have driven the current cancer chemotherapy to intently focus on development of target-based approaches rather ... -
Pyrimidine-fused derivatives: Synthetic strategies and medicinal attributes
(Bentham Science Publishers B.V., 2016)Pyrimidine-fused derivatives traits the inextricable part of DNA and RNA, exhibit indispensable role in numerous biological processes, possessing momentous chemical and biological importance. Pyrimidine-condensed derivatives ... -
Epidermal Growth Factor Receptor (EGFR) and its Cross-Talks with Topoisomerases: Challenges and Opportunities for Multi-Target Anticancer Drugs
(Bentham Science Publishers B.V., 2016)Background: The interactions of Epidermal Growth Factor Receptor (EGFR) and topoisomerases have been seen in various cancer including brain, breast, ovarian, colorectal, gastric, etc. Methods: The studies in adenocarcinoma ... -
Cystathionine β-Lyase-Like Protein with Pyridoxal Binding Domain Characterized in Leishmania major by Comparative Sequence Analysis and Homology Modelling
(Hindawi, 2013)Cystathionine β-lyase-like protein (CBLP), one of the key enzymes involved in methionine biosynthesis utilising pyridoxal phosphate (PLP) as a cofactor, has recently been reported in Leishmania major. Its presence in the ... -
Pyrimidine containing epidermal growth factor receptor kinase inhibitors: Synthesis and biological evaluation
(Blackwell Publishing Ltd, 2017)Structure-based design and synthesis of pyrimidine containing reversible epidermal growth factor receptor (EGFR) inhibitors 1a?d are reported. The compounds (1a?d) inhibited the EGFR kinase activity in vitro with IC50 range ... -
Natural products based ayurvedic formulations: Chemical constituents and treatment in neurodegenerative disorders
(Bentham Science Publishers B.V., 2017)Neurodegenerative diseases are linked with high morbidity and mortality rates. Medical science has made considerable progress in understanding the mechanisms associated with the development of the neurodegenerative diseases. ... -
1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway
(Wiley-VCH Verlag, 2014)A series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative ... -
A comprehensive review on bioactive fused heterocycles as purine-utilizing enzymes inhibitors
(Birkhauser Boston, 2015)Purine-utilizing enzymes (PUEs) are involved in the control of biological actions of nitrogen-containing bases, purines and pyrimidines, by participating in their catabolism, and this has made them a topic of considerate ... -
Growth factors mediated cell signalling in prostate cancer progression: Implications in discovery of anti-prostate cancer agents.
(Elsevier, 2015)Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer is one of the most encountered malignancies among men. Globally, it is the sixth leading cause of cancer-related death ... -
Synthesis and biological evaluation of new 2, 5- dimethylthiophene/furan based N-acetyl pyrazolines as selective topoisomerase II inhibitors
(Royal Society of Chemistry, 2016)Based on the reported pharmacophores as topoiomerase inhibitors, 2,5 dimethylthiophen/furan based N-acetyl pyrazolines were designed and envisaged as topoisomerase inhibitors. The target compounds were synthesized and ... -
Identification of new insulin growth factor receptor-1 (IGF-1R) inhibitors via exploring ATPas kinase domain of IGF-1R through virtual screening
(Birkhauser Boston, 2017)Insulin growth factor receptor-1 is a trans-membrane tyrosine kinase receptor that mediates the polypeptide protein hormone insulin growth factor-1, responsible for normal function and growth of human cells. The overexpression ...