Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Subject "Antineoplastic agent"
Now showing items 1-2 of 2
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Pyrimidine containing epidermal growth factor receptor kinase inhibitors: Synthesis and biological evaluation
(Blackwell Publishing Ltd, 2017)Structure-based design and synthesis of pyrimidine containing reversible epidermal growth factor receptor (EGFR) inhibitors 1a?d are reported. The compounds (1a?d) inhibited the EGFR kinase activity in vitro with IC50 range ... -
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity
(2013)Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar ...