Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Subject "Cancer"
Now showing items 1-10 of 14
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Epidermal growth factor receptor and its trafficking regulation by acetylation: Implication in resistance and exploring the newer therapeutic avenues in cancer
(Bentham Science Publishers, 2020)Background: The EGFR is overexpressed in numerous cancers. So, it becomes one of the most favorable drug targets. Single-acting EGFR inhibitors on prolong use induce resistance and side effects. Inhibition of EGFR and/or ... -
Flavonoids as P-glycoprotein inhibitors for multidrug resistance in cancer: an in-silico approach
(Taylor and Francis Ltd., 2022-09-19)Cancer has become a leading cause of mortality due to non-communicable diseases after cardiovascular disease worldwide and is increasing day by day at a daunting pace. According to an estimate by 2040 there will be 28.4 ... -
Identification of 1,3,4-oxadiazoles as tubulin-targeted anticancer agents: a combined field-based 3D-QSAR, pharmacophore model-based virtual screening, molecular docking, molecular dynamics simulation, and density functional theory calculation approach
(Taylor and Francis Ltd., 2023-09-11)Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial protein of cytoskeleton that maintains essential cellular functions including cell division as well as cell signalling, that makes an ... -
Impact of cannabinoid receptors in the design of therapeutic agents against human ailments
(Bentham Science Publishers, 2023-05-03)The Cannabinoid (CB) signalling cascade is widely located in the human body and is associated with several pathophysiological processes. The endocannabinoid system comprises cannabinoid receptors CB1 and CB2, which belong ... -
Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1? inhibitors
(Taylor and Francis Ltd., 2022-03-23)Hypoxia-inducible factor (HIF) is a transcriptional factor which plays a crucial role in tumour metastasis thereby responsible for development of various forms of cancers. Indazole derivatives have been reported in the ... -
Pore-forming proteins and their role in cancer and inflammation: Mechanistic insights and plausible druggable targets
(Elsevier Ireland Ltd, 2022-08-30)Perforin is a granular effector pore-forming protein formed in NK cells and Cytotoxic T lymphocytes. These cytotoxic proteins are part of the first-line immune defense in the human body. They ensure apoptosis of pathogen-infected ... -
Rationalization of the activity Profile of Pyruvate Kinase Isozyme M2 (PKM2) Inhibitors using 3D QSAR
(Bentham Science Publishers, 2021-08-05)Introduction: Pyruvate kinase isozyme M2 (PKM2) was observed to be overexpressed and play a key role in cell growth and cancer cells' metabolism. During the past years, phytochemicals have been developed as new treatment ... -
Recent Advancements in Small Molecule Inhibitors of Insulin–like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase as Anticancer agents
(Bentham Science, 2013)Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer in human, have driven the current cancer chemotherapy to intently focus on development of target-based approaches rather ... -
Role of peroxisome proliferator-activated receptor gamma (Ppar?) in different disease states: Recent updates
(Bentham Science Publishers, 2020-07-17)Peroxisome proliferator-activated receptor (PPAR), a ligand dependant transcription factor, is a member of the nuclear receptor superfamily. PPAR exists in three isoforms i.e. PPAR alpha (PPAR?), PPAR beta (PPAR?), and ... -
Steering the antitumor drug discovery campaign towards structurally diverse indolines
(Academic Press Inc., 2020)Indoline framework is often perpended as a privileged heterocycle present in medicinally valuable compounds of natural and synthetic origin. This review article presents the rational approaches/strategies employed for the ...