Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Subject "Human"
Now showing items 1-10 of 13
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Anticancer activity of essential oils: A review
(2013)Natural essential oil constituents play an important role in cancer prevention and treatment. Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, ... -
Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles
(2012)Silver nanoparticles (Ag NPs) are used in consumer products and wound dressings due to their antimicrobial properties. However, in addition to toxic effects on microbes, Ag NPs can also induce stress responses as well as ... -
Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study
(Elsevier Ltd, 2016)Vitamin D deficiency is implicated in multiple disease conditions and accumulating evidence supports that the variation in serum vitamin D (25(OH)D) levels, including deficiency, is under strong genetic control. However, ... -
In silico study of flavonoids as DPP-4 and α-glucosidase inhibitors
(Bentham Science Publishers B.V., 2018)Background: Diabetes being among the most prevalent disease is being studied widely to achieve most potent drug with lesser side-effects. Numerous targets have been explored and several drugs have been developed to combat ... -
Interaction model of steviol glycosides from Stevia rebaudiana (Bertoni) with sweet taste receptors: A computational approach
(Elsevier Ltd, 2015)Docking studies were performed on natural sweeteners from Stevia rebaudiana by constructing homology models of T1R2 and T1R3 subunits of human sweet taste receptors. Ramachandran plot, PROCHECK results and ERRAT overall ... -
Intracellular delivery of redox cycler-doxorubicin to the mitochondria of cancer cell by folate receptor targeted mitocancerotropic liposomes
(2012)Cancer cells reflect higher level of ROS in comparison to the normal cell, so they become more vulnerable to further oxidative stress induced by exogenous ROS-generating agents. Through this a novel therapeutic strategy ... -
A Perspective on Monoamine Oxidase Enzyme as Drug Target: Challenges and Opportunities
(2017)The monoamine oxidase (MAO) enzyme is responsible for the deamination of monoamine neurotransmitters and regulates their concentration in the central and peripheral nervous systems. Imbalance in the concentration of ... -
Promising targets in anti-cancer drug development: Recent updates
(Bentham Science Publishers B.V., 2017)Cancer is a multifactorial disease and its genesis and progression are extremely complex. The biggest problem in the anticancer drug development is acquiring of multidrug resistance and relapse. Classical chemotherapeutics ... -
Pyrazoloquinazolines: Synthetic strategies and bioactivities
(2015)Numerous N-heterocycles are indisputably evidenced to exhibit myriad biological activities. In the recent past, attempts made to condense the various heterocycles have resulted in derivatives possessing better bioactivities. ... -
Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling
(Academic Press, 2015)Despite the fact that radiation therapy is a highly effective therapeutic approach, a small intratumoral cell subpopulation known as "cancer stem cells" (CSCs) is radiation-resistant and possesses specific molecular ...