Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Subject "Humans"

Now showing items 1-10 of 10

    • Anticancer activity of essential oils: A review 

      Bhalla, Yashika; Gupta, Vinay Kumar; Jaitak, Vikas (2013)
      Natural essential oil constituents play an important role in cancer prevention and treatment. Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, ...

    • Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles 

      Singh, R.P.; Ramarao, P. (2012)
      Silver nanoparticles (Ag NPs) are used in consumer products and wound dressings due to their antimicrobial properties. However, in addition to toxic effects on microbes, Ag NPs can also induce stress responses as well as ...

    • Interaction model of steviol glycosides from Stevia rebaudiana (Bertoni) with sweet taste receptors: A computational approach 

      Mayank; Jaitak, Vikas; Mayank, Jaitak, V. (Elsevier Ltd, 2015)
      Docking studies were performed on natural sweeteners from Stevia rebaudiana by constructing homology models of T1R2 and T1R3 subunits of human sweet taste receptors. Ramachandran plot, PROCHECK results and ERRAT overall ...

    • A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2 

      Arora, Sahil; Joshi, Gaurav; Chaturvedi, Anuhar; Heuser, Michael; Patil, Santoshkumar; Kumar, Raj (American Chemical Society, 2021-11-02)
      The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ...

    • A Perspective on Monoamine Oxidase Enzyme as Drug Target: Challenges and Opportunities 

      Kumar, Bhupinder; Gupta, Vivek Prakash; Kumar, Vinod (2017)
      The monoamine oxidase (MAO) enzyme is responsible for the deamination of monoamine neurotransmitters and regulates their concentration in the central and peripheral nervous systems. Imbalance in the concentration of ...

    • PROTAC�ing oncoproteins: targeted protein degradation for cancer therapy 

      Kelm, Jeremy M.; Pandey, Deepti S.; Malin, Evan; Kansou, Hussein; Arora, Sahil; Kumar, Raj; Gavande, Navnath S. (BioMed Central Ltd, 2023-03-30)
      Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target ...

    • Pyrazoloquinazolines: Synthetic strategies and bioactivities 

      Garg, Mansi; Chauhan, Monika; Singh, Pankaj Kumar; Singh, Pankaj Kumar; Alex, Jimi Marin; Kumar, Raj (2015)
      Numerous N-heterocycles are indisputably evidenced to exhibit myriad biological activities. In the recent past, attempts made to condense the various heterocycles have resulted in derivatives possessing better bioactivities. ...

    • Synthesis of rebaudioside A from stevioside and their interaction model with hTAS2R4 bitter taste receptor 

      Singla, Ramit; Jaitak, Vikas (Elsevier Ltd, 2016)
      Steviol glycosides (SG's) from Stevia rebaudiana (Bertoni) have been used as a natural low-calorie sweeteners. Its aftertaste bitterness restricts its use for human consumption and limits its application in food and ...

    • Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities 

      Maity, Pritam; Chatterjee, Joydeep; Patil, Kiran T.; Arora, Sahil; Katiyar, Madhurendra K.; Kumar, Manvendra; Samarbakhsh, Amirreza; Joshi, Gaurav; Bhutani, Priyadeep; Chugh, Manoj; Gavande, Navnath S.; Kumar, Raj (American Chemical Society, 2023-02-22)
      Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role in several cellular functions including cancer cell growth, survival, proliferation, differentiation, and motility. Several ...

    • U.S. FDA Approved Drugs from 2015-June 2020: A Perspective 

      Bhutani, Priyadeep; Joshi, Gaurav; Raja, Nivethitha; Bachhav, Namrata; Rajanna, Prabhakar K.; Bhutani, Hemant; Paul, Atish T.; Kumar, Raj (American Chemical Society, 2021-02-22)
      In the present work, we report compilation and analysis of 245 drugs, including small and macromolecules approved by the U.S. FDA from 2015 until June 2020. Nearly 29% of the drugs were approved for the treatment of various ...