Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Subject "Review"

Now showing items 1-8 of 8

    • Anticancer activity of essential oils: A review 

      Bhalla, Yashika; Gupta, Vinay Kumar; Jaitak, Vikas (2013)
      Natural essential oil constituents play an important role in cancer prevention and treatment. Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, ...

    • MEK inhibitors in cancer treatment: structural insights, regulation, recent advances and future perspectives 

      Ram, Teja; Singh, Ankit Kumar; Kumar, Adarsh; Singh, Harshwardhan; Pathak, Prateek; Grishina, Maria; Khalilullah, Habibullah; Jaremko, Mariusz; Emwas, Abdul-Hamid; Verma, Amita; Kumar, Pradeep (Royal Society of Chemistry, 2023-08-10)
      MEK1/2 are critical components of the RAS-RAF-MEK-ERK or MAPK signalling pathway that regulates a variety of cellular functions including proliferation, survival, and differentiation. In 1997, a lung cancer cell line was ...

    • A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2 

      Arora, Sahil; Joshi, Gaurav; Chaturvedi, Anuhar; Heuser, Michael; Patil, Santoshkumar; Kumar, Raj (American Chemical Society, 2021-11-02)
      The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ...

    • Promising targets in anti-cancer drug development: Recent updates 

      Kumar, Bhupinder; Singh, Sandeep; Skvortsova, Ira; Kumar, Vinod (Bentham Science Publishers B.V., 2017)
      Cancer is a multifactorial disease and its genesis and progression are extremely complex. The biggest problem in the anticancer drug development is acquiring of multidrug resistance and relapse. Classical chemotherapeutics ...

    • PROTAC�ing oncoproteins: targeted protein degradation for cancer therapy 

      Kelm, Jeremy M.; Pandey, Deepti S.; Malin, Evan; Kansou, Hussein; Arora, Sahil; Kumar, Raj; Gavande, Navnath S. (BioMed Central Ltd, 2023-03-30)
      Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target ...

    • Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling 

      Skvortsov, Ira; Debbage, Paul; Kumar, Vinod; Skvortsov, Sergej (Academic Press, 2015)
      Despite the fact that radiation therapy is a highly effective therapeutic approach, a small intratumoral cell subpopulation known as "cancer stem cells" (CSCs) is radiation-resistant and possesses specific molecular ...

    • Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities 

      Maity, Pritam; Chatterjee, Joydeep; Patil, Kiran T.; Arora, Sahil; Katiyar, Madhurendra K.; Kumar, Manvendra; Samarbakhsh, Amirreza; Joshi, Gaurav; Bhutani, Priyadeep; Chugh, Manoj; Gavande, Navnath S.; Kumar, Raj (American Chemical Society, 2023-02-22)
      Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role in several cellular functions including cancer cell growth, survival, proliferation, differentiation, and motility. Several ...

    • U.S. FDA Approved Drugs from 2015-June 2020: A Perspective 

      Bhutani, Priyadeep; Joshi, Gaurav; Raja, Nivethitha; Bachhav, Namrata; Rajanna, Prabhakar K.; Bhutani, Hemant; Paul, Atish T.; Kumar, Raj (American Chemical Society, 2021-02-22)
      In the present work, we report compilation and analysis of 245 drugs, including small and macromolecules approved by the U.S. FDA from 2015 until June 2020. Nearly 29% of the drugs were approved for the treatment of various ...