Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Subject "SAR"
Now showing items 1-10 of 11
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Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
(Elsevier Masson SAS, 2015)Abstract Coumarins are fused benzene and pyrone ring systems which prompt biological investigation to assess their potential therapeutic significance. It possesses immeasurable anticancer potential with minimum side effects ... -
Effectiveness of Selective Estrogen Receptor Modulators in Breast Cancer Therapy: An Update
(Bentham Science Publishers, 2022-10-06)Background: Breast cancer is considered to be 2nd most common cancer sub-type investigated worldwide. It is mainly prevalent in postmenopausal women. Estrogen Receptor (ER) is a primary transcription factor for the survival ... -
Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review
(2013)Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble purines which prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial ... -
Medicinal chemistry aspects and synthetic strategies of coumarin as aromatase inhibitors: an overview
(Springer, 2022-12-05)Coumarin is a bicyclic oxygen bearing heterocyclic scaffold formed by fusion of benzene with the pyrone ring. Because of its unique physicochemical characteristics and the ease with which it may be transformed into a wide ... -
The medicinal perspective of 2,4-thiazolidinediones based ligands as antimicrobial, antitumor and antidiabetic agents: A review
(John Wiley and Sons Inc, 2022-06-18)2,4-Thiazolidinedione (2,4-TZD), commonly known as glitazone, is a ubiquitous heterocyclic pharmacophore possessing a plethora of pharmacological activities and offering a vast opportunity for structural modification. The ... -
Recent Advancements in Small Molecule Inhibitors of Insulin–like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase as Anticancer agents
(Bentham Science, 2013)Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer in human, have driven the current cancer chemotherapy to intently focus on development of target-based approaches rather ... -
Recent Developments in Oxazole Derivatives as Anticancer Agents: Review on Synthetic Strategies, Mechanism of Action and SAR Studies
(Bentham Science Publishers, 2021-09-16)Background: Cancer is the world�s third deadliest disease. Despite the availability of numerous treatments, researchers are focusing on the development of new drugs with no resistance and toxicity issues. Many newly ... -
Recent developments of C-4 substituted coumarin derivatives as anticancer agents
(Elsevier Masson SAS, 2016)Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand ... -
Synthetic Methodologies and SAR of Quinazoline Derivatives as PI3K Inhibitors
(Bentham Science Publishers, 2023-01-19)PI3K is an important anticancer target as it controls cellular functions such as growth, transformation, pro-liferation, motility and differentiation. Plasma cell cancer (multiple myeloma) occurs more than 10% among all ... -
Tetrazoles as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
(Elsevier, 2020)Cancer is a leading cause of death worldwide. Even after the availability of numerous drugs and treatments in the market, scientists and researchers are focusing on new therapies because of their resistance and toxicity ...