Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Subject "cancer chemotherapy"
Now showing items 1-2 of 2
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Mechanisms of tubulin binding ligands to target cancer cells: Updates on their therapeutic potential and clinical trials
(Bentham Science Publishers B.V., 2017)Background: A number of chemically diverse substances bind to the tubulin and inhibit cell proliferation by disrupting microtubule dynamics. There are four binding sites for the ligands binding to the tubulin; taxane/epothilone ... -
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2
(American Chemical Society, 2021-11-02)The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ...