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Ganoderic acid, lanostanoid triterpene: a key player in apoptosis
(Springer New York LLC, 2018)
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell ...
Ganoderic Acid A Targeting ?-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study
(Springer Berlin Heidelberg, 2018)
Wnt signaling pathways are the group of signaling transduction controlling the embryonic development, cell proliferation, cell migration, cell fate specification, and body axis pattern. Nuclear accumulation of ?-catenin ...
Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators
(Elsevier Ltd, 2018)
Ground breaking clinical therapeutic advances in the treatment of breast cancer (BC) is the introduction of selective estrogen receptor modulators (SERMs). We have expeditiously designed and synthesized indole-xanthendione ...
In silico screening and molecular interaction studies of tetrahydrocannabinol and its derivatives with acetylcholine binding protein
(Bentham Science Publishers B.V., 2018)
Background: Alzheimer’s disease (AD) is the fourth largest cause of death among people over 65 years of age. Accumulation of β-amyloid and cholinergic deficiency are two prominent pathological descriptions for AD.
Objective: ...
Transcriptome characterization and screening of molecular markers in ecologically important Himalayan species (Rhododendron arboreum)
(Canadian Science Publishing, 2018)
Rhododendron arboreum is an ecologically prominent species, which also lends commercial and medicinal benefits in the form of palatable juices and useful herbal drugs. Local abundance and survival of the species under a ...
Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)
(Springer, 2018)
Purpose
Despite a growing body of evidence indicating a potential efficacy of the anti-diabetic metformin as anti-cancer agent, the exact mechanism underlying this efficacy has remained largely unknown. Here, we aimed at ...
Exploring microRNA profiles for circadian clock and flowering development regulation in Himalayan Rhododendron
(Elsevier, 2018)
miRNA is a non-coding, yet crucial entity in remodeling the genetic architecture. Rhododendron arboreum of Himalayas grows and even flower under fluctuating climate. sRNA from leaves of vegetative and reproductive periods ...
S961, a biosynthetic insulin receptor antagonist, downregulates insulin receptor expression & suppresses the growth of breast cancer cells
(Indian Council of Medical Research (ICMR), 2018)
Background & objectives: Insulin resistance associated with hyperinsulinaemia and overexpression of insulin receptors (IRs) have been intricately linked to the pathogenesis and treatment outcomes of the breast carcinoma. ...
RNAseq-based phylogenetic reconstruction of Taxaceae and Cephalotaxaceae
(Wiley, 2018)
Taxaceae and Cephalotaxaceae are the two economically important conifer families. Over the years there has been much controversy over the issue of merging these families. The position of Amentotaxus and Torreya is also ...
Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma
(Springer, 2018)
Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma ...