RSS 1.0Department of Pharmaceutical Sciences and Natural Products
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Recent Submissions
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Synthesis and Biological Evaluation of Inhibitors of Topoisomerases and Histone Deacetylase for In Vitro Anticancer Activity
(Central University of Punjab, 2019)Topoisomerases (Topos) and histone deacetylases (HDACs) are validated oncotherapeutic targets due to their involvement in most of the cellular events such as initiation, proliferation, and survival of cancer cells. Widespread ... -
Design, Synthesis and Evaluation of Indole Based Compounds as Putative Anticancer Agents
(Central University of Punjab, 2018)In the course of efforts to develop new chemotherapeutic agent for targeting breast cancer, indole-benzimidazole, indole-xanthendione, indole-chromene carbonitrile and indole-dihydropyridine derivatives were computationally ... -
SYNTHESIS AND ANTICANCER EVALUATION OF NOVEL HETEROCYCLICS DERIVED FROM IMIDAZOLE AND QUINOLINE SCAFFOLDS
(Central University of Punjab, 2018) -
Design, Synthesis and Evaluation of Donepezil-Rasagiline Based Compounds as Multipotent Inhibitors for the Treatment of Alzheimer’s Disease
(Central University of Punjab, 2019)Alzheimer’s disease (AD) is multifactorial in nature and different enzymes including MAO, AChE, and amyloid beta are implicated in its pathogenesis. The pathomechanism of AD is complex in nature and single target drugs ... -
Targeting cancer stem cells pathways for the effective treatment of cancer
(Bentham Science Publishers, 2020)Resistance to chemotherapy and relapse are major hurdles for the effective treatment of cancer. Major reason for this is a small sub population of cancer stem cells (CSCs) and its microenvironment. CSCs are critical driving ... -
Epidermal growth factor receptor and its trafficking regulation by acetylation: Implication in resistance and exploring the newer therapeutic avenues in cancer
(Bentham Science Publishers, 2020)Background: The EGFR is overexpressed in numerous cancers. So, it becomes one of the most favorable drug targets. Single-acting EGFR inhibitors on prolong use induce resistance and side effects. Inhibition of EGFR and/or ... -
A review on quinoline derivatives as anti-methicillin resistant Staphylococcus aureus (MRSA) agents
(BioMed Central Ltd., 2020)Methicillin Resistant Staphylococcus aureus (MRSA) consists of strains of S. aureus which are resistant to methicillin. The resistance is due to the acquisition of mecA gene which encodes PBP2a unlike of any PBPs normally ... -
Tetrazoles as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
(Elsevier, 2020)Cancer is a leading cause of death worldwide. Even after the availability of numerous drugs and treatments in the market, scientists and researchers are focusing on new therapies because of their resistance and toxicity ... -
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters
(Springer, 2020)Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present ... -
Global trends in pesticides: A looming threat and viable alternatives
(Academic Press, 2020)Pesticides are widely used chemical compounds in agriculture to destroy insects, pests and weeds. In modern era, they form an indispensable part of agricultural and health practices. Globally, nearly 3 billion kg of ... -
E-pharmacophore guided discovery of pyrazolo[1,5-c]quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase
(Academic Press Inc., 2020)In the quest to ameliorate the camptothecin (CPT) downsides, we expedite to search for stable non-CPT analogues among 11 motifs of pyrazoloquinazolines reported. E-pharmacophore drug design approach helped filtering out ... -
Metal- And Solvent-Free Multicomponent Decarboxylative A3-Coupling for the Synthesis of Propargylamines: Experimental, Computational, and Biological Investigations
(American Chemical Society, 2020)Decarboxylative A3-coupling of ortho-hydroxybenzaldehydes, secondary amines, and alkynoic acids is performed under catalyst and solvent-free conditions. The developed methodology provided a waste-free method for the synthesis ... -
Steering the antitumor drug discovery campaign towards structurally diverse indolines
(Academic Press Inc., 2020)Indoline framework is often perpended as a privileged heterocycle present in medicinally valuable compounds of natural and synthetic origin. This review article presents the rational approaches/strategies employed for the ... -
A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors
(Elsevier Ltd, 2020)Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates its biological roles through a hexameric ... -
P53-mediated anticancer activity of Citrullus colocynthis extracts
(Bentham Science Publishers, 2019)Background: Current anticancer therapeutics comes with significant side effects and thus focus is shifting towards minimizing the side effects or to avoid the disease altogether. Thus, various natural products are being ... -
Recent development in indole derivatives as anticancer agents for breast cancer
(Bentham Science Publishers, 2019)Background: Breast Cancer (BC) is the second most common cause of cancer related deaths in women. Due to severe side effects and multidrug resistance, current therapies like hormonal therapy, surgery, radiotherapy and ... -
Plant-derived natural alkaloids as new antimicrobial and adjuvant agents in existing antimicrobial therapy
(Bentham Science Publishers, 2019)Infectious diseases, instigated by pathogenic microorganisms are the cause of numerous health problems in developing countries. Infectious diseases got a place in the list of top ten death causes worldwide. The reason ... -
A review on quinoline derived scaffolds as anti-HIV agents
(Bentham Science Publishers, 2019)After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable ... -
Recent advances in decarboxylative C-C bond formation using direct or in situ generated alkenyl acids
(Taylor and Francis Inc., 2019)In recent years, the reactions of abundantly available, inexpensive, and structurally diverse alkenyl acids (-C=C-COOH) with C-X (X = halogen) or C-H coupling partner have emerged as vital strategies for the streamlined ... -
Stevia rebaudiana targeting ?-amylase: An in-vitro and in-silico mechanistic study
(Taylor and Francis Ltd., 2019)Diabetes mellitus (DM) is the fastest growing metabolic disorder in the world. Recently, more attention is paid to the study of natural products due to side effects of synthetic drugs. Stevia rebaudiana (Bertoni) is ...
