Department of Pharmaceutical Sciences and Natural Products
Collections in this Department
Recent Submissions
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Design and Fabrication of a Nanobiosensor for the Detection of Cell-Free Circulating miRNAS-LncRNAS-mRNAS Triad Grid
(American Chemical Society, 2023-10-18)The increased understanding of the competitive endogenous RNA (ceRNA) network in the onset and development of breast cancers has suggested their use as promising disease biomarkers. Keeping these RNAs as molecular targets, ... -
Polycystic ovary syndrome: Current scenario and future insights
(Elsevier Ltd, 2023-11-05)Polycystic ovary syndrome (PCOS) prevails in approximately 33% of females of reproductive age globally. Although the root cause of the disease is unknown, attempts are made to clinically manage the disturbed hormone levels ... -
Oxazoline/amide derivatives against M. tuberculosis: experimental, biological and computational investigations
(Taylor and Francis Ltd., 2023-11-10)Tuberculosis (TB) is a treatable contagious disease that continuously kills approximately 2 million people yearly. Different oxazoline/amide derivatives were synthesized, and their anti-tuberculosis activity was performed ... -
Design, one-pot synthesis, computational and biological evaluation of diaryl benzimidazole derivatives as MEK inhibitors
(Taylor and Francis Ltd., 2023-10-09)MEK mutations are more common in various human malignancies, such as pancreatic cancer (70�90%), mock melanoma (50%), liver cancer (20�40%), colorectal cancer (25�35%), melanoma (15�20%), non-small cell lung cancer (10�20%) ... -
Boron in cancer therapeutics: An overview
(Elsevier Inc., 2023-10-17)Boron has become a crucial weapon in anticancer research due to its significant intervention in cell proliferation. Being an excellent bio-isosteric replacement of carbon, it has modulated the anticancer efficacy of various ... -
Current insights and molecular docking studies of HIV-1 reverse transcriptase inhibitors
(John Wiley and Sons Inc, 2023-10-12)Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), a lethal disease that is prevalent worldwide. According to the Joint United Nations Programme on HIV/AIDS (UNAIDS) data, 38.4 million ... -
Medicinal Chemistry Aspects of Isoxazole Analogues as Anti-tubercular Agents
(Bentham Science Publishers, 2023-10-11)Tuberculosis (TB) is the major cause of mortality around the world and one of the most common diseases linked to AIDS. Due to the emergence of multi-drug resistance, extensive drug resistance, and total drug resistance ... -
Dihydropyrimidinone scaffold and potential therapeutic targets
(Elsevier, 2023-08-25)Dihydropyrimidine is the most important heterocyclic ring system involved in the synthesis of RNA and DNA. Dihydropyrimidines were produced synthetically by multicomponent reactions such as the Biginelli reaction. Because ... -
Identification of 1,3,4-oxadiazoles as tubulin-targeted anticancer agents: a combined field-based 3D-QSAR, pharmacophore model-based virtual screening, molecular docking, molecular dynamics simulation, and density functional theory calculation approach
(Taylor and Francis Ltd., 2023-09-11)Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial protein of cytoskeleton that maintains essential cellular functions including cell division as well as cell signalling, that makes an ... -
Applications of dihydropyrimidinone derivatives on blood cancer and colon cancer
(Elsevier, 2023-08-25)Dihydropyrimidinones (DHPMs) are characterized by their multifunctionalized scaffold with a pyrimidine moiety that exhibits diverse biological activities, especially anticancer activity. Malignant clonal expansion of ... -
Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications
(Academic Press Inc., 2023-09-18)Nucleic acid represents the ideal drug candidate for protein targets that are hard to target or against which drug development is not easy. Peptide nucleic acids (PNAs) are synthesized by attaching modified peptide backbones ... -
MEK inhibitors in cancer treatment: structural insights, regulation, recent advances and future perspectives
(Royal Society of Chemistry, 2023-08-10)MEK1/2 are critical components of the RAS-RAF-MEK-ERK or MAPK signalling pathway that regulates a variety of cellular functions including proliferation, survival, and differentiation. In 1997, a lung cancer cell line was ... -
Phytochemical Profiling and Pharmacological Evaluation of Leaf Extracts of Ruellia tuberosa L.: An In Vitro and In Silico Approach
(John Wiley and Sons Inc, 2023-08-04)The present study was designed to appraise the photoprotective, antioxidant, and antibacterial bioactivities of Ruellia tuberosa leaves extracts (RtPE, RtChl, RtEA, RtAc, RtMe, and RtHMe). The results showed that, RtHMe ... -
Developing our knowledge of the quinolone scaffold and its value to anticancer drug design
(Taylor and Francis Ltd., 2023-08-18)Introduction: The quinolone scaffold is a bicyclic benzene-pyridinic ring scaffold with nitrogen at the first position and a carbonyl group at the second or fourth position. It is endowed with a diverse spectrum of ... -
Probing the molecular mechanisms of ?-synuclein inhibitors unveils promising natural candidates through machine-learning QSAR, pharmacophore modeling, and molecular dynamics simulations
(Institute for Ionics, 2023-07-18)Parkinson�s disease is characterized by a multifactorial nature that is linked to different pathways. Among them, the abnormal deposition and accumulation of ?-synuclein fibrils is considered a neuropathological hallmark ... -
A review on reported phytochemicals as druggable leads with antimalarial potential
(Springer, 2023-07-04)The science and practice of drug discovery and development is primarily benefitted from the natural sources. The chemistry of natural products has inspired medicinal chemists to develop and design various therapeutic ... -
Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022
(American Chemical Society, 2023-07-26)Serine/threonine-protein kinase B-Raf (BRAF; RAF = rapidly accelerated fibrosarcoma) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade. Somatic mutations in the BRAF gene were first ... -
In Silico Studies of Indole Derivatives as Antibacterial Agents
(Korean Pharmacopuncture Institute, 2023-06-30)Objectives: Molecular docking and QSAR studies of indole derivatives as antibacterial agents. Methods: In this study, we used a multiple linear regressions (MLR) approach to construct a 2D quantitative structure activity ... -
Thioether linkage chemistry: perspectives and prospects in therapeutic designing
(Elsevier, 2023-07-07)Polymer�drug conjugates (PDCs) are an emerging approach for the development of targeted drug delivery systems for chemotherapeutic agents possessing poor pharmacokinetic properties. Development of PDCs offers an advantage ... -
Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs
(Elsevier Ireland Ltd, 2023-05-22)Alzheimer's disease (AD), also called senile dementia, is the most common neurological disorder. Around 50 million people, mostly of advanced age, are suffering from dementia worldwide and this is expected to reach 100�130 ...