Browsing Department of Pharmaceutical Sciences and Natural Products by Issue Date
Now showing items 1-20 of 298
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Augmented anticancer efficacy of doxorubicin-loaded polymeric nanoparticles after oral administration in a breast cancer induced animal model
(2011)The present investigation reports an extensive evaluation of in vitro and in vivo anticancer efficacy of orally administered doxorubicin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Dox-NPs) in a breast cancer ... -
Intracellular delivery of redox cycler-doxorubicin to the mitochondria of cancer cell by folate receptor targeted mitocancerotropic liposomes
(2012)Cancer cells reflect higher level of ROS in comparison to the normal cell, so they become more vulnerable to further oxidative stress induced by exogenous ROS-generating agents. Through this a novel therapeutic strategy ... -
Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles
(2012)Silver nanoparticles (Ag NPs) are used in consumer products and wound dressings due to their antimicrobial properties. However, in addition to toxic effects on microbes, Ag NPs can also induce stress responses as well as ... -
Insulin resistance induces a segmental difference in thoracic and abdominal aorta: Differential expression of AT1 and AT2 receptors
(2012)Objectives: The study was pursued to understand and compare the vascular reactivity to angiotensin II (Ang II) and its receptor expression in thoracic and abdominal aorta under insulin resistance. Methods: Vascular reactivity ... -
Anticancer activity of essential oils: A review
(2013)Natural essential oil constituents play an important role in cancer prevention and treatment. Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, ... -
Recent Advancements in Small Molecule Inhibitors of Insulin–like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase as Anticancer agents
(Bentham Science, 2013)Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer in human, have driven the current cancer chemotherapy to intently focus on development of target-based approaches rather ... -
Cystathionine β-Lyase-Like Protein with Pyridoxal Binding Domain Characterized in Leishmania major by Comparative Sequence Analysis and Homology Modelling
(Hindawi, 2013)Cystathionine β-lyase-like protein (CBLP), one of the key enzymes involved in methionine biosynthesis utilising pyridoxal phosphate (PLP) as a cofactor, has recently been reported in Leishmania major. Its presence in the ... -
Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review
(2013)Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble purines which prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial ... -
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity
(2013)Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar ... -
In-vitro anti-mutagenic activity of Asparagus racemosus: An ayurvedic medicinal plant
(Academic Journals Inc., 2013)Asparagus racemosus is a plant traditionaly used in epilepsy, as a brain tonic, cardiac disorders, hypertension, habitual abortions, weakness of the uterus, excessive bleeding during menstruation. The current study evaluated ... -
Accumulated polymer degradation products as effector molecules in cytotoxicity of polymeric nanoparticles
(2013)Polymeric nanoparticles (PNPs) are a promising platform for drug, gene, and vaccine delivery. Although generally regarded as safe, the toxicity of PNPs is not well documented. The present study investigated in vitro toxicity ... -
Recent advancements in small molecule inhibitors of insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase as anticancer agents
(2013)Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer in human, have driven the current cancer chemotherapy to intently focus on development of target-based approaches rather ... -
Surfactant-assisted dispersion of carbon nanotubes: Mechanism of stabilization and biocompatibility of the surfactant
(2013)Nanoparticles (NPs) are thermodynamically unstable system and tend to aggregate to reduce free energy. The aggregation property of NPs results in inhomogeneous exposure of cells to NPs resulting in variable cellular ... -
Anticancer potential of new n-acetyl pyrazoline derivatives of 1,3 diaryl/hetroaryl propenoes: Synethesis and evaluation
(Central University of Punjab, 2013)Pyrazoles, categorized as nitrogen-containing heterocycles, are well known for their interminable participation in the field of perpetual research and development of therapeutical active agents. As a consequence pyrazoles ... -
In-vitro guided fractionation of crude root extracts of potentilla atrosanguinea lodd and in-silico of polyphenolic compounds
(Central University of Punjab, 2013)Modern therapeutic system is a kind of inspiration from traditional plant based medicine used for various diseases and ailments. Advancement in drug discovery technology including computational drug design and bioassay ... -
Synethesis and biochemical screening of novel non-purine based xanthine oxidase inhibitors
(Central University of Punjab, 2013)Xanthine oxidase (XO), or xanthine oxidoreductase (XOR), is a complex molybdoflavoenzyme which, in humans, is recognized as the terminal enzyme of purine catabolism, catalysing the hydroxylation of purines to uric acid, ... -
Phytochemical investigation in vitro anti-mutagenic activity of potentilla fulgens lodd and silico study of flavonoids with CDK-2,CDK-6 receptors
(Central University of Punjab, 2013)Plants have been used for thousand years in the treatment of various diseases. Plant secondary metabolites have proved to be an excellent source of new medicinal compounds. They offer protection against variety of chronic ... -
Integrated in-vitro antioxidant and in-silico anti-apoptotic study of essential oil components of aconitum heterophyllum wall
(Central University of Punjab, 2013)Aconitum heterophyllum Wall. is consumed for its promising medicinal properties in several parts of the world. Present study consists of hydrodistillation, antioxidant potential and in-silico antiapoptotic study of A. ... -
Chemical profiling of ganoderma lucidum of bathinda region
(Central University of Punjab, 2013)Ganoderma lucidum is a basidiomycete's fungus with numerous pharmacological properties. The important ingredients of Ganoderma lucidum are terpenoids and polysaccharides etc. which play momentous role in immunomodulating, ... -
Phytochemical investigation and biological evaluation of secondary metabolites from asparagus racemosus l through in-vitro and in-silico approach
(Central University of Punjab, 2013)Nature has been a source of medicinal products for millennia, and with many useful drugs developed from different natural resources, with majority of drugs are from plant origin. Asparagus racemosus belonging to family ...