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New approaches to target cancer stem cells: Current scenario
(2014)
Resistance towards chemotherapy and radiotherapy as well as relapse of cancer is the major obstacle in the treatment of cancer. The main factor behind is cancer stem cells (CSCs) which are more resistant to conventional ...
Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists
(Elsevier, 2014)
Opioid ligands have found use in a number of therapeutic areas, including for the treatment of pain and opiate addiction (using agonists) and alcohol addiction (using antagonists such as naltrexone and nalmefene). The ...
1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway
(Wiley-VCH Verlag, 2014)
A series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative ...
SHATAVARI (ASPARAGUS RACEMOSUS WILD): A REVIEW ON ITS CULTIVATION, MORPHOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGICAL IMPORTANCE
(web of Science (Thomson Reuters), 2014)
Asparagus racemosus, a climbing Ayurvedic plant, is known for its numerous activities such as hyperlipidemia, hypertension, angina, dysmenorrhea, anxiety disorders, benign prostatic hyperplasia (BPH), leucorrhoea and urinary ...
Chemical composition and biological effects of artemisia maritima and artemisia nilagirica essential oils from wild plants of Western Himalaya
(Georg Thieme Verlag, 2014)
Artemisia species possess pharmacological properties that are used for medical purposes worldwide. In this paper, the essential oils from the aerial parts of Artemisia nilagirica and Artemisia maritima from the western ...
Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/ Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
(ACS Publications, 2014)
Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy ...
4,5-Dihydro-1H-pyrazole: An indispensable scaffold
(Informa Healthcare, 2014)
Pyrazoles, categorized as nitrogen-containing heterocycles, are well known for their interminable participation in the field of perpetual research and development of therapeutical active agents. As a consequence pyrazoles ...
Synthesis and xanthine oxidase inhibitory activity of 5,6 dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives
(Elsevier, 2014)
Some 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives were rationally designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity ...
Microwave-assisted synthesis of pyrazolo[1,5-c]quinazolines and their derivatives
(Elsevier, 2014)
Microwave accelerated and expedited cyclocondensation reactions of 2-(3-aryl-1H-pyrazol-5-yl)anilines (4) with diverse aryl aldehydes/triethyl orthoformate in water/MeCN (route D) and internal cyclocondensation and ...
Impact of ABC transporters, glutathione conjugates in MDR and their modulation by flavonoids: An overview
(2014)
Overexpression of ATP-binding cassette (ABC) transporter and glutathione conjugates results in efflux of cytotoxic agent from tumor cells leading to multidrug resistance (MDR). Many MDR inhibitors have been identified but ...