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Antiproliferative activity of Asparagus racemosus extracts
(Central University of Punjab, 2018)
Cancer is regarded as uncontrolled progression and spread of cells. Cancer is not
a singular, specific disease but a group of variable tissue responses that result in
uncontrolled cell growth. Healthy cells have a specific ...
Design, Synthesis and Evaluation of Indole Based Compounds as Putative Anticancer Agents
(Central University of Punjab, 2018)
In the course of efforts to develop new chemotherapeutic agent for targeting breast cancer, indole-benzimidazole, indole-xanthendione, indole-chromene carbonitrile and indole-dihydropyridine derivatives were computationally ...
Recent development in indole derivatives as anticancer agents for breast cancer
(Bentham Science Publishers, 2019)
Background: Breast Cancer (BC) is the second most common cause of cancer related deaths in women. Due to severe side effects and multidrug resistance, current therapies like hormonal therapy, surgery, radiotherapy and ...
Identification of novel indole based heterocycles as selective estrogen receptor modulator.
(Elsevier, 2018)
In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ...
Drug Targeting Strategies in Breast Cancer Treatment
(Bentham Science, 2014)
Breast cancer (BC) is the leading cause of death among women all over the world. Estrogen receptor (ER) based therapy is one of the major approaches to target BC and is associated with various problems such as primary as ...
Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-?)
(Elsevier Masson SAS, 2018)
In the course of efforts to develop novel selective estrogen receptor modulators (SERMs), indole-benzimidazole hybrids were designed and synthesised by fusing the indole nucleus with benzimidazole. All the compounds were ...
De novo designing, assessment of target affinity and binding interactions against aromatase: Discovery of novel leads as anti-breast cancer agents
(Springer, 2020-11-13)
Aromatase inhibitors (AIs) have been emerged as promising anti-cancer agents for the treatment of hormone dependent breast cancer (HDBC) in women because of their excellent ability of inhibiting oestrogen synthesis. Here, ...
Hetero Cyclic Compounds in the Treatment of Triple-Negative Breast Cancer
(Bentham Science Publishers, 2023-01-02)
Triple-negative breast cancer (TNBC) holds just about 15% of all breast tumours and sub-types of breast cancer with distinct characteristics of negative expressions for the progesterone recep-tor, estrogen receptor, and ...
Medicinal chemistry aspects and synthetic strategies of coumarin as aromatase inhibitors: an overview
(Springer, 2022-12-05)
Coumarin is a bicyclic oxygen bearing heterocyclic scaffold formed by fusion of benzene with the pyrone ring. Because of its unique physicochemical characteristics and the ease with which it may be transformed into a wide ...
In silico molecular interaction studies of chitosan polymer with aromatase inhibitor: Leads to letrozole nanoparticles for the treatment of breast cancer
(Bentham Science Publishers, 2020-08-26)
Background: It takes a lot more studies to evaluate the molecular interaction of nanoparticles with the drug, their drug delivery potential and release kinetics. Thus, we have taken in silico and in vitro approaches into ...