Browsing Human Genetics and Molecular Medicine-Research Publications by Title
Now showing items 144-163 of 256
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KIBRA Team Up with Partners to Promote Breast Cancer Metastasis
(Springer, 2019)Among women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized ... -
Large-Scale Characterization of the Soil Microbiome in Ancient Tea Plantations Using High-Throughput 16S rRNA and Internal Transcribed Spacer Amplicon Sequencing
(Frontiers Media S.A., 2021-10-16)There is a special interaction between the environment, soil microorganisms, and tea plants, which constitute the ecosystem of tea plantations. Influenced by environmental factors and human management, the changes in soil ... -
Lessons Learned from Cohort Studies, and Hospital-Based Studies and Their Implications in Precision Medicine
(Elsevier Inc., 2017)Advances in human genomics and cutting-edge technologies have created space for integrating personalized or precise medicine into the practice of medicine and thereby improving the public health. Achieving the goal of ... -
Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4
(BioMed Central Ltd, 2021-11-27)Background and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional ... -
Long non-coding RNAs involved in different steps of cancer metastasis
(Springer Science and Business Media Deutschland GmbH, 2022-02-04)Non-proteincoding transcripts bearing 200 base pairs known as long non-coding RNAs (lncRNAs) play a role in a variety of molecular mechanisms, including cell differentiation, apoptosis and metastasis. Previous studies have ... -
A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity
(2012)Two common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association ... -
Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives
(MDPI, 2022-11-01)Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous ... -
Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling
(Springer, 2019)Cancer, the leading causes of death worldwide, causes multiple metabolic and physiological alterations, leading to an unregulated proliferation of cells. The existing anticancer therapies are usually nonspecific with side ... -
Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review
(John Wiley and Sons Ltd, 2023-01-30)Background: Recurrent pregnancy loss is defined as the loss of two or more pregnancies and is a distressing condition for couples. Objective: To investigate the relationship between variants in the candidate susceptibility ... -
Measuring routine childhood vaccination coverage in 204 countries and territories, 1980�2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1
(Elsevier B.V., 2021-07-21)Background: Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization ... -
Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
(Routledge, 2020)Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, ... -
Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
(Routledge, 2020-06-17)Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, ... -
Melittin: a possible regulator of cancer proliferation in preclinical cell culture and animal models
(Springer Science and Business Media Deutschland GmbH, 2023-11-03)Background: Melittin is a water-soluble cationic peptide derived from bee venom that has been thoroughly studied for the cure of different cancers. However, the unwanted interactions of melittin produce hemolytic and ... -
Mesenchymal stem cells- an excellent therapeutic agent for cancer
(John Wiley and Sons Inc, 2023-05-16)Despite rapid advancement in research of diagnostics and therapeutics, cancer is the most dangerous disease-causing millions of deaths worldwide. Many of the conventional anticancer therapies can even lead to developing ... -
Meta-analysis confirmed genetic susceptibility conferred by multiple risk variants from CTLA4 and SERPINA1 in granulomatosis with polyangiitis
(John Wiley and Sons Inc, 2022-06-03)Background: Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease. Smaller sample size and complex nature of the disease pathogenesis has made it challenging to perform well-powered genetic investigations. ... -
A meta-analysis suggests the association of reduced serum level of vitamin D and T-allele of Fok1 (rs2228570) polymorphism in the vitamin D receptor gene with celiac disease
(Frontiers Media S.A., 2023-01-19)Purpose: As an immune-modulator, vitamin D is known to regulate immune response and is implicated in disease pathogenesis. Celiac disease (CD) is a systemic autoimmune disease and susceptibility conferred by vitamin D ... -
Microbiome in Pulmonary Tuberculosis
(Springer Nature, 2022-03-25)Tuberculosis (TB) is among the global dominant fatal infection caused by a single organism, and it is still holding its position in spite of the golden age of the antibiotics. The recent studies are mostly focused on finding ... -
Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration
(Frontiers Media S.A., 2021-04-13)Microglia, a type of innate immune cell of the brain, regulates neurogenesis, immunological surveillance, redox imbalance, cognitive and behavioral changes under normal and pathological conditions like Alzheimer�s, ... -
Midgut aminopeptidase N expression profile in castor semilooper (Achaea janata) during sublethal Cry toxin exposure
(Springer, 2021-03-19)The midgut of lepidopteran larvae is a multifunctional tissue that performs roles in digestion, absorption, immunity, transmission of pathogens and interaction with ingested various molecules. The proteins localized at the ...