Browsing Human Genetics and Molecular Medicine-Research Publications by Title
Now showing items 178-197 of 256
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Nanotheranostics revolutionizing neurodegenerative diseases: From precision diagnosis to targeted therapies
(Editions de Sante, 2023-10-16)Neurodegenerative disorders pose a significant burden on global healthcare systems, and the development of effective therapeutics and diagnostics remains a critical challenge. Nanotheranostics, the integration of ... -
Natural Compound-Based Nanoparticles to Target Free Radicals in Cancer
(Springer Singapore, 2022-09-28)Cell proliferation and malignant transformation are enabled by genetic and epigenetic changes. During the malignancy process, malignant cells acquire distinguishing characteristics. Cancer cells have acquired the ability ... -
Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD)
(Springer, 2023-11-22)Depression is a complex psychiatric disorder influenced by various genetic and environmental factors. Strong evidence has established the contribution of genetic factors in depression through twin studies and the heritability ... -
A novel 7 bp deletion in PRPF31 associated with autosomal dominant retinitis pigmentosa with incomplete penetrance in an Indian family
(2012)To localize and identify the gene linked with non-syndromic autosomal dominant retinitis pigmentosa (adRP) with high but not complete penetrance in an Indian family. A detailed family history and clinical data were recorded. ... -
Obesity-Induced Chronic Low-Level Inflammation and Cancers
(Springer Singapore, 2021-07-18)The World Health Organization (WHO) has highlighted �overweight and obesity� as a public health concern and a significant risk factor for several chronic diseases, including diabetes, cardiovascular diseases, and cancers. ... -
Oncogenic metabolic reprogramming in breast cancer: focus on signaling pathways and mitochondrial genes
(Springer, 2023-05-11)Oncogenic metabolic reprogramming impacts the abundance of key metabolites that regulate signaling and epigenetics. Metabolic vulnerability in the cancer cell is evident from the Warburg effect. The research on metabolism ... -
Oxidative stress and inflammation in cardiovascular diseases: Two sides of the same coin
(Springer India, 2015)Globally, the major cause of long- term disability and death is an ?epidemiologic transition? from infectious diseases and malnutrition complications to non-communicable chronic diseases like cardiovascular disease (CVD), ... -
Oxidative stress and inflammation in diabetic complications
(Hindawi Publishing Corporation, 2014) -
Oxidative Stress Events and Neuronal Dysfunction in Alzheimer’s Disease: Focus on APE1/Ref-1-Mediated Survival Strategies
(Springer, 2014)Alzheimer’s disease (AD) is an important public health problem which affects millions of people worldwide. The major pathological hallmarks associated with AD are the accumulation of amyloid beta (Aβ) in senile plaques and ... -
Oxidative stress in the development of genetic generalised epilepsy: An observational study in southern Indian population
(Journal of Clinical and Diagnostic Research, 2017)Introduction: Oxidative stress resulting from excessive generation of Reactive Oxygen Species (ROS) plays a significant role in neurodegeneration associated with seizures/epilepsy. Aim: To evaluate oxidative stress markers ... -
Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives
(Elsevier Inc., 2022-04-07)Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide. It is characterized by pancreatic insulin resistance and ?-cell dysfunction. Hyperglycemia induced reactive oxygen species (ROS) production ... -
P47 phox2/2 Mice Are Compromised in Expansion and Activation of CD8 + T Cells and Susceptible to Trypanosoma cruzi Infection
(Public Library of Science (PLOS), 2014)Macrophage activation of NAD(P)H oxidase (NOX2) and reactive oxygen species (ROS) is suggested to kill Trypanosoma cruzi that causes Chagas disease. However, the role of NOX2 in generation of protective immunity and whether ... -
P53-mediated anticancer activity of Citrullus colocynthis extracts
(Bentham Science Publishers, 2019)Background: Current anticancer therapeutics comes with significant side effects and thus focus is shifting towards minimizing the side effects or to avoid the disease altogether. Thus, various natural products are being ... -
Pd-Catalyzed Four-Component Sequential Reaction Delivers a Modular Fluorophore Platform for Cell Imaging
(American Chemical Society, 2019)A Pd-catalyzed cascade reaction of four versatile privileged synthons is described. The sequential reaction involves the formation of five new chemical bonds by concatenating three distinct chemical steps. One of the ... -
Pesticide Induced Cytotoxicity Analysis in Human Cells
(Krishi Sanskriti Publications, 2017)The aim of our work was to evaluate the effect of pesticides on cell survival, oxidative stress mechanism in hPBMC (human Peripheral Blood Mononucleated Cells) and lung cancer cells (A549 cell line). Cells were exposed to ... -
Pharmacogenetics of Cyclophosphamide and Doxorubicin in Breast Cancer & Synthesis and Biological Evaluation of New Imidazole Based Putative Anticancer Agents
(Central University of Punjab, 2019)Breast cancer is the second most prevalent cancer in women worldwide. It is treated by various strategies, including surgery, radiation therapy, hormonal therapy, targeted therapy and chemotherapy. Chemotherapeutic drugs ... -
Pharmacogenomics of GLP-1 receptor agonists: Focus on pharmacological profile
(Elsevier B.V., 2022-10-28)Type 2 Diabetes mellitus (T2DM) is a multifactorial metabolic disorder also known as a silent killer disease. Macrovascular and microvascular complications associated with diabetes worsen the condition leading to higher ... -
Pharmacological and molecular approaches for the treatment of β- hemoglobin disorders
(Wiley, 2017)β-hemoglobin disorders, such as β-thalassemia and sickle cell anemia are among the most prevalent inherited genetic disorders worldwide. These disorders are caused by mutations in the gene encoding hemoglobin-β (HBB), a ... -
�The pharmacological profile of SGLT2 inhibitors: Focus on mechanistic aspects and pharmacogenomics�
(Elsevier B.V., 2021-05-11)Diabetes, characterized by high glucose levels, has been listed to be one of the world's major causes of death. Around 1.6 million deaths are attributed to this disease each year. Persistent hyperglycemic conditions in ... -
Potential use of cidofovir, brincidofovir, and tecovirimat drugs in fighting monkeypox infection: recent trends and advancements
(Springer Science and Business Media Deutschland GmbH, 2023-10-14)Recent years have witnessed the rise of more recent pandemic outbreaks including COVID-19 and monkeypox. A multinational monkeypox outbreak creates a complex situation that necessitates countermeasures to the existing quo. ...