Browsing Human Genetics and Molecular Medicine-Research Publications by Title
Now showing items 223-242 of 256
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Safety and ethics in biotechnology and bioengineering: What to follow and what not to
(Elsevier Inc., 2017)Biotechnology and bioengineering are disciplines of science, which use knowledge of biological sciences and advanced technologies to generate new and useful products and processes for the benefit of society. The potential ... -
Serum Albumin Levels in Breast Cancer: Correlation with Overall Survival
(SciTechnol, 2017)Introduction: Albumin in an important biomarker that indicates malnutrition as well as inflammation. The aim of the study was to evaluate the albumin levels in breast cancer patients and its association with overall survival ... -
Serum homocysteine could be used as a predictive marker for chronic obstructive pulmonary disease: A meta-analysis
(Frontiers Media S.A., 2019)Background: Serum homocysteine (Hcy) level is inversely related with concentration of folic acid, which is an essential micronutrient for metabolism and energy homeostasis. Serum concentrations of Hcy have been reported ... -
Shared and unique common genetic determinants between pediatric and adult celiac disease
(BioMed Central Ltd., 2016)Background: Based on age of presentation, celiac disease (CD) is categorised as pediatric CD and adult CD. It however remains unclear if these are genetically and/or phenotypically distinct disorders or just different ... -
Small regulatory molecules acting big in cancer: Potential role of mito-miRs in cancer
(Bentham Science Publishers, 2019)MicroRNAs [miRNAs] are short, non-coding, single stranded RNA molecules regulating gene expression of their targets at the posttranscriptional level by either degrading mRNA or by inhibiting translation. Previously, miRNAs ... -
SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
(Frontiers Media S.A., 2021-12-02)miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported ... -
A Spectrum of Solutions: Unveiling Non-Pharmacological Approaches to Manage Autism Spectrum Disorder
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-08-31)Autism spectrum disorder (ASD) is a developmental disorder that causes difficulty while socializing and communicating and the performance of stereotyped behavior. ASD is thought to have a variety of causes when accompanied ... -
Stem cells in the treatment of Alzheimer's disease � Promises and pitfalls
(Elsevier B.V., 2023-04-06)Alzheimer's disease (AD) is the most widespread form of neurodegenerative disorder that causes memory loss and multiple cognitive issues. The underlying mechanisms of AD include the build-up of amyloid-? and phosphorylated ... -
Structural assembly of Polycomb group protein and Insight of EZH2 in cancer progression: A review
(Wolters Kluwer Medknow Publications, 2020-10-13)Polycomb group proteins (PcG) are multi-subunit structure, consisting of polycomb repressive complex 1 (PRC1), PRC2/3, and pleiohomeotic repressive complex. PRC1 is made up of PHC, BMI-1, CBX, and Ring 1A/B. PRC2 protein ... -
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors
(Elsevier Masson SAS, 2017)There are around 20 Cyclin-dependent kinases (CDKs) known till date, and various research groups have reported their role in different types of cancer. The X-ray structures of some CDKs especially CDK2 was exploited in the ... -
Studies on Genomic Alterations in HER2-Positive Breast Cancer–Focus on Design, Synthesis & Evaluation of Anilinoquinazoline Analogues as Potential HER2 inhibitors
(Central University of Punjab, 2019)Human epidermal growth factor receptor 2-positive (HER2-positive) breast cancer is an aggressive breast cancer subtype characterized by HER2 overexpression/amplification. Genomic alterations of HER2 and others have been ... -
A study of mechanistic mapping of novel SNPs to male breast cancer
(Humana Press Inc., 2019)Alterations in BRCA2, PALB2, CHEK2, and p53 genes have been identified for their association with male breast cancer in various studies. The incidence of male breast cancer in India is consistent with its global rate. The ... -
Synthesis of gadolinium oxide nanocuboids for in vitro bioimaging applications
(Institute of Physics Publishing, 2019)Undoped and Eu-doped gadolinium oxide (GGNCs and EGNCs) nanocuboids functionalized with D-gluconic acid (GA) were synthesised by a simple yet unique scheme using all the benign solvents and temperature. Samples were ... -
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity
(2013)Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar ... -
Synthetic versus enzymatic pictet-spengler reaction: An overview
(Bentham Science Publishers B.V., 2018)Background: Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having ... -
Synthetic versus Enzymatic Pictet-Spengler Reaction: An Overview.
(Bentham, 2018)Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having immense biological ... -
Systematic review and meta-analysis confirms significant contribution of surfactant protein D in chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)Background: Surfactant protein D (SFTPD) is a lung specific protein which performs several key regulatory processes to maintain overall lung function. Several infectious and immune mediated diseases have been shown to be ... -
Systematic review and meta-analysis to establish the association of common genetic variations in Vitamin D binding protein with chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)Background: Vitamin-D binding protein (DBP) also known as GC protein, is a major determinant for vitamin- D metabolism and transport. GC1F, GC1S, and GC2 are the three allelic variants (denoted as rs4588 and rs7041) of GC, ... -
A systematic review of the monogenic causes of Non-Syndromic Hearing Loss (NSHL) and discussion of Current Diagnosis and Treatment options
(John Wiley and Sons Inc, 2022-09-12)Hearing impairment is one of the most widespread inheritable sensory disorder affecting at least 1 in every 1000 born. About two-third of hereditary hearing loss (HHL) disorders are non-syndromic. To provide comprehensive ...