Browsing Human Genetics and Molecular Medicine-Research Publications by Subject "Cancer"
Now showing items 1-10 of 12
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Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells
(Springer, 2018)Caulerpa taxifolia (M. Vahl) C. Agardh or killer alga is known to possess several bioactive secondary metabolites with unique structural modifications. We investigated anti-oxidant and anti-proliferative activity of C. ... -
Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells
(De Gruyter, 2019)Caulerpa taxifolia (M. Vahl) C. Agardh or killer alga is known to possess several bioactive secondary metabolites with unique structural modifications. We investigated anti-oxidant and anti-proliferative activity of C. ... -
Design, Synthesis and Biological Evaluation of New 5-(2-Nitrophenyl)-1-aryl-1H-pyrazoles as Topoisomerase Inhibitors
(John Wiley and Sons Inc, 2021-07-09)5-(2-Nitrophenyl)-1-aryl-1H-pyrazoles are designed as topoisomerase (Topo) inhibitors, synthesised and assessed for their anticancer properties against breast (MDA-MB-231 and MCF7), lung (A549), and colorectal (HCT116) ... -
Differential molecular mechanistic behavior of HDACs in cancer progression
(Springer, 2022-08-16)Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors in controlling cancer development. ... -
Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4
(BioMed Central Ltd, 2021-11-27)Background and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional ... -
Long non-coding RNAs involved in different steps of cancer metastasis
(Springer Science and Business Media Deutschland GmbH, 2022-02-04)Non-proteincoding transcripts bearing 200 base pairs known as long non-coding RNAs (lncRNAs) play a role in a variety of molecular mechanisms, including cell differentiation, apoptosis and metastasis. Previous studies have ... -
Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling
(Springer, 2019)Cancer, the leading causes of death worldwide, causes multiple metabolic and physiological alterations, leading to an unregulated proliferation of cells. The existing anticancer therapies are usually nonspecific with side ... -
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis
(Springer Science and Business Media Deutschland GmbH, 2022-11-28)ROS include hydroxyl radicals (HO.), superoxide (O2.), and hydrogen peroxide (H2O2). ROS are typically produced under physiological conditions and play crucial roles in living organisms. It is known that ROS, which are ... -
Obesity-Induced Chronic Low-Level Inflammation and Cancers
(Springer Singapore, 2021-07-18)The World Health Organization (WHO) has highlighted �overweight and obesity� as a public health concern and a significant risk factor for several chronic diseases, including diabetes, cardiovascular diseases, and cancers. ... -
Role of Hedgehog and Hippo signaling pathways in cancer: A special focus on non-coding RNAs
(Academic Press, 2022-10-28)Despite advanced clinical and translational oncology research, mortality rates are still increasing worldwide. Recently, a class of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and ...