Browsing Human Genetics and Molecular Medicine-Research Publications by Subject "Histone deacetylases"
Now showing items 1-2 of 2
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Differential molecular mechanistic behavior of HDACs in cancer progression
(Springer, 2022-08-16)Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors in controlling cancer development. ... -
E-pharmacophore guided discovery of pyrazolo[1,5-c]quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase
(Academic Press Inc., 2020)In the quest to ameliorate the camptothecin (CPT) downsides, we expedite to search for stable non-CPT analogues among 11 motifs of pyrazoloquinazolines reported. E-pharmacophore drug design approach helped filtering out ...