Browsing Human Genetics and Molecular Medicine-Research Publications by Subject "Molecular docking"
Now showing items 1-3 of 3
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Design, Synthesis, and Anticancer Evaluation of Hemithioindigos via Inhibition of Human Topoisomerases
(John Wiley and Sons Inc, 2023-11-06)Hemithioindigos were designed as topoisomerase inhibitors, synthesized, and evaluated for their anticancer properties against lung (A549) and breast (MDA-MB-468 and MCF7) cancer cell lines. Among all the synthetics, three ... -
Electro-organic synthesis of C-5 sulfenylated amino uracils: Optimization and exploring topoisomerase-I based anti-cancer profile
(Academic Press Inc., 2023-06-10)Cancer is spreading worldwide and is one of the leading causes of death. The use of existing chemotherapeutic agents is frequently limited due to side effects. As a result, it is critical to investigate new agents for ... -
In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation
(Taylor and Francis Ltd., 2018)Despite the various research efforts toward the treatment of stress-related disorders, the drug has not yet launched last 20?years. Corticotropin releasing factor-1 receptor antagonists have been point of great interest ...