Browsing Human Genetics and Molecular Medicine-Research Publications by Subject "camptothecin; messenger RNA; nutlin 3; protein p21; protein p53; regulator protein; short hairpin RNA; transducer of Cdc42 dependent actin assembly 1; unclassified drug; carrier protein; FNBP1L protein, human; messenger RNA; protein p53; Toca-1 protein, rat; TP53 protein, human; vesicular transport adaptor protein; animal experiment; Article; breast cancer; cancer cell culture; chromatin immunoprecipitation; controlled study; human; human cell; immunoblotting; immunohistochemistry; in vitro stud"
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Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
(BioMed Central Ltd., 2014)Introduction: Transducer of Cdc42-dependent actin assembly-1 (Toca-1) recruits actin regulatory proteins to invadopodia, and promotes breast tumor metastasis. Since metastatic breast tumors frequently harbor mutations in ...