Browsing Human Genetics and Molecular Medicine-Research Publications by Subject "miRNA"
Now showing items 1-6 of 6
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Combinatorial Effect of DCA and Let-7a on Triple-Negative MDA-MB-231 Cells: A Metabolic Approach of Treatment
(SAGE Publications Inc., 2020)Dichloroacetate (DCA) is a metabolic modulator that inhibits pyruvate dehydrogenase activity and promotes the influx of pyruvate into the tricarboxylic acid cycle for complete oxidation of glucose. DCA stimulates oxidative ... -
Common microRNAs in Epilepsy and Migraine: Their Possibility as Can-didates for Biomarkers and Therapeutic Targets during Comorbid Onset of Both Conditions
(Bentham Science Publishers, 2022-04-27)Epilepsy and migraine are chronic neurological disorders with shared clinical as well as pathophysiological mechanisms. Epileptic patients are at a higher risk of developing migraine compared to normal individuals and vice ... -
Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
(Springer Science and Business Media Deutschland GmbH, 2023-04-24)MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational repression. The aberrant expression of various miRNAs has been associated with ... -
miRNA dysregulation in ischaemic stroke: Focus on diagnosis, prognosis, therapeutic and protective biomarkers
(Blackwell Publishing Ltd, 2020)Stroke is one of the leading causes of death and disability in both developing and developed countries. Biomarkers for stroke and its outcome can greatly facilitate early detection and management of the disease. miRNAs ... -
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis
(Springer Science and Business Media Deutschland GmbH, 2022-11-28)ROS include hydroxyl radicals (HO.), superoxide (O2.), and hydrogen peroxide (H2O2). ROS are typically produced under physiological conditions and play crucial roles in living organisms. It is known that ROS, which are ... -
SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
(Frontiers Media S.A., 2021-12-02)miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported ...