RSS 1.0Pharmaceutical Sciences and Natural Products-Master Dissertation
Recent Submissions
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Antiproliferative activity of Asparagus racemosus extracts
(Central University of Punjab, 2018)Cancer is regarded as uncontrolled progression and spread of cells. Cancer is not a singular, specific disease but a group of variable tissue responses that result in uncontrolled cell growth. Healthy cells have a specific ... -
Synthesis of Benzazepinone Derivatives as Anticancer Agents
(Central University of Punjab, 2018)Cancer is a disease which starts uncontrolled development of cell as it loses its essential structure and usefulness and that may go ahead to assault and destroy neighboring tissues. Cyclin dependent kinase have major role ... -
Synthesis and in silico studies of pyrazoline containing quinoline derivatives as anti-HIV agents
(Central University of Punjab, 2018)Quinoline moiety is an important scaffold in the field of drug discovery and drug development with wide range of pharmacological activities. Its derivatives are potent inhibitors for reverse transcriptase which is responsible ... -
Antiproliferative Activity of Chloroform and Methanol Extracts of Piper attenuatum (Buch-Ham)
(Central University of Punjab, 2018)Indian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antiproliferative activity. Dried powder of fruits of Piper attenuatum (Buch-Ham) was subjected to maceration to prepare various ... -
Synthesis and In Silico Studies Of Quinazolinone Derivatives As PARP-1 INHIBITORS
(Central University of Punjab, 2018)Cancer is one of the leading diseases responsible for high mortality rates worldwide. It develops when normal cells begin to grow out of control in particular part of the body. Cancer is a leading cause of death worldwide, ... -
Synthesis And Antiproliferative Activity Of Pyrazole-Based Heterocycles
(Central University of Punjab, 2018)Among the various heterocyclic compounds pyrazole and its derivatives have occupied wide range of biological and pharmacological activities. These were observed for their modes of function in the inhibition of topoisomerase ... -
Chemical Investigation and Antiproliferative screening of extracts from Stevia rebaudiana (Bertoni)
(Central University of Punjab, 2018)Cancer is the uncontrolled development of abnormal cells in the body. It is considered as the leading public health problem in both developed and the developing countries. As no drug of cancer is establish to be completely ... -
Synthesis And Biological Evaluation Of Pyrimidine Bridged Biphenyls As Putative Ligands To Target Parkinson's Disease
(Central University of Punjab, 2018)MAO inhibitors have been explored as therapeutic agents for the treatment or management of PD. A series of 2,4,6-trisubstituted pyrimidine derivatives incorporating a propargyl moiety were synthesized and screened for their ... -
3-D QSAR Study Of Combretastatins Fused With Hetrocyclic Ring As Tubulin Binding Agents
(Central University of Punjab, 2018)Combretastatin A4 (CA4) is a leading agent in vascular disrupting strategies and tubulin polymerization inhibitor for the tumour therapy. A large number of combretastatin derivatives have been synthesized as potent ... -
Synthesis and Characterization of Pyridine and Pyrimidine Derivatives
(Central University of Punjab, 2018)Pyridine and pyrimidine derivatives are important chemical compounds with tremendous biological applications. Fusion of pyrimidine moiety with different heterocycle scaffolds gives rise to a new class of hybrid heterocycles ... -
Phytochemical investigation of natural sweetener from stevia rebaudiana (Bartoni)
(Central University of Punjab, 2014)S. rebaudiana is an important plant because of the high concentration of steviol glycosides (SGs). Sugars and artificial sweeteners, which are used in general as well as in pharmaceutical field have shown multiple toxic ... -
Synthesis and characterization of 2-aminothiophene derivatives by Gewald reaction
(Central University of Punjab, 2018)Substituted thiophene derivatives are very important heterocycles found in many biologically active and natural compounds. The Gewald multicomponent reaction was a remarkable discovery for the synthesis of wide variety of ... -
Synthesis, Characterization and Biological Evaluation of 5-(2- Nitrophenyl)-1H-Pyrazole Derivatives as Putative Antiproliferative Agents
(Central University of Punjab, 2018)Pyrazoles are known to exhibit various biological activities like antibacterial, antiprotozoal, anticonvulsant, analgesic, anti-inflammatory, antiviral and antiproliferative. An attempt has been made to synthesize substituted ... -
Synethesis of some piperazine containing scataining scaffolds as potential MAO inhibitors
(Central University of Punjab, 2014)Ficus benghalensis and Ficus religiosa commonly known as Banyan and Peepal trees (or Bodhi) respectively, are important tropical trees that are being grown and traditionally revered throughout Indian subcontinent for ... -
Design and synethesis of APE1 inhibitors as putative anticancer agents
(Central University of Punjab, 2014)Success in chemotherapy has not been attained completely yet and has remained a worried issue from years. Various reasons drive this failure, but the much talked about is failure due to emergence of resistance to ... -
Anticancer activity of cassia fistula linn through invitro and insilicoapproach
(Central University of Punjab, 2014)Cassia fistula L. (Leguminoseae) is a plant species called "Aragvadha" that means "disease killer". C. fistula consists of plethora of medicinal properties. A detailed discussion is depicted of the therapeutic potential ... -
In vitro and In silico study of Essential oil Components from Eucalyptus tereticornis as Antibacterial agents
(Central University of Punjab, 2018)Many essential oils are known for their antimicrobial activity and the main target is bacterial cell membrane which is important for bacterial viability and hence the study was done to find the target and effective binding ... -
Design and synethesis of putative anti-cancer agents using hybrid molecular approach
(Central University of Punjab, 2014)A Hybrid drug involves the unification of two drug pharmacophores in one single molecule. The hybrid drugs are designed to interact with multiple targets or to intensify its effect through action on another bio target as ... -
Imidazole based compunds: Synethesis and in vitro anticancer screening
(Central University of Punjab, 2013)Imidazole is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron rich characteristic is ... -
Synethesis and biochemical screening of novel non-purine based xanthine oxidase inhibitors
(Central University of Punjab, 2013)Xanthine oxidase (XO), or xanthine oxidoreductase (XOR), is a complex molybdoflavoenzyme which, in humans, is recognized as the terminal enzyme of purine catabolism, catalysing the hydroxylation of purines to uric acid, ...
