Browsing Pharmaceutical Sciences and Natural Products-Master Dissertation by Issue Date
Now showing items 1-20 of 25
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Anticancer potential of new n-acetyl pyrazoline derivatives of 1,3 diaryl/hetroaryl propenoes: Synethesis and evaluation
(Central University of Punjab, 2013)Pyrazoles, categorized as nitrogen-containing heterocycles, are well known for their interminable participation in the field of perpetual research and development of therapeutical active agents. As a consequence pyrazoles ... -
In-vitro guided fractionation of crude root extracts of potentilla atrosanguinea lodd and in-silico of polyphenolic compounds
(Central University of Punjab, 2013)Modern therapeutic system is a kind of inspiration from traditional plant based medicine used for various diseases and ailments. Advancement in drug discovery technology including computational drug design and bioassay ... -
Synethesis and biochemical screening of novel non-purine based xanthine oxidase inhibitors
(Central University of Punjab, 2013)Xanthine oxidase (XO), or xanthine oxidoreductase (XOR), is a complex molybdoflavoenzyme which, in humans, is recognized as the terminal enzyme of purine catabolism, catalysing the hydroxylation of purines to uric acid, ... -
Phytochemical investigation in vitro anti-mutagenic activity of potentilla fulgens lodd and silico study of flavonoids with CDK-2,CDK-6 receptors
(Central University of Punjab, 2013)Plants have been used for thousand years in the treatment of various diseases. Plant secondary metabolites have proved to be an excellent source of new medicinal compounds. They offer protection against variety of chronic ... -
Integrated in-vitro antioxidant and in-silico anti-apoptotic study of essential oil components of aconitum heterophyllum wall
(Central University of Punjab, 2013)Aconitum heterophyllum Wall. is consumed for its promising medicinal properties in several parts of the world. Present study consists of hydrodistillation, antioxidant potential and in-silico antiapoptotic study of A. ... -
Phytochemical investigation and biological evaluation of secondary metabolites from asparagus racemosus l through in-vitro and in-silico approach
(Central University of Punjab, 2013)Nature has been a source of medicinal products for millennia, and with many useful drugs developed from different natural resources, with majority of drugs are from plant origin. Asparagus racemosus belonging to family ... -
Imidazole based compunds: Synethesis and in vitro anticancer screening
(Central University of Punjab, 2013)Imidazole is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron rich characteristic is ... -
Phytochemical investigation of natural sweetener from stevia rebaudiana (Bartoni)
(Central University of Punjab, 2014)S. rebaudiana is an important plant because of the high concentration of steviol glycosides (SGs). Sugars and artificial sweeteners, which are used in general as well as in pharmaceutical field have shown multiple toxic ... -
Synethesis of some piperazine containing scataining scaffolds as potential MAO inhibitors
(Central University of Punjab, 2014)Ficus benghalensis and Ficus religiosa commonly known as Banyan and Peepal trees (or Bodhi) respectively, are important tropical trees that are being grown and traditionally revered throughout Indian subcontinent for ... -
Anticancer activity of cassia fistula linn through invitro and insilicoapproach
(Central University of Punjab, 2014)Cassia fistula L. (Leguminoseae) is a plant species called "Aragvadha" that means "disease killer". C. fistula consists of plethora of medicinal properties. A detailed discussion is depicted of the therapeutic potential ... -
Design and synethesis of APE1 inhibitors as putative anticancer agents
(Central University of Punjab, 2014)Success in chemotherapy has not been attained completely yet and has remained a worried issue from years. Various reasons drive this failure, but the much talked about is failure due to emergence of resistance to ... -
Design and synethesis of putative anti-cancer agents using hybrid molecular approach
(Central University of Punjab, 2014)A Hybrid drug involves the unification of two drug pharmacophores in one single molecule. The hybrid drugs are designed to interact with multiple targets or to intensify its effect through action on another bio target as ... -
Antiproliferative activity of Asparagus racemosus extracts
(Central University of Punjab, 2018)Cancer is regarded as uncontrolled progression and spread of cells. Cancer is not a singular, specific disease but a group of variable tissue responses that result in uncontrolled cell growth. Healthy cells have a specific ... -
Synthesis of Benzazepinone Derivatives as Anticancer Agents
(Central University of Punjab, 2018)Cancer is a disease which starts uncontrolled development of cell as it loses its essential structure and usefulness and that may go ahead to assault and destroy neighboring tissues. Cyclin dependent kinase have major role ... -
Chemical Investigation and Antiproliferative screening of extracts from Stevia rebaudiana (Bertoni)
(Central University of Punjab, 2018)Cancer is the uncontrolled development of abnormal cells in the body. It is considered as the leading public health problem in both developed and the developing countries. As no drug of cancer is establish to be completely ... -
In vitro and In silico study of Essential oil Components from Eucalyptus tereticornis as Antibacterial agents
(Central University of Punjab, 2018)Many essential oils are known for their antimicrobial activity and the main target is bacterial cell membrane which is important for bacterial viability and hence the study was done to find the target and effective binding ... -
Antiproliferative Activity of Chloroform and Methanol Extracts of Piper attenuatum (Buch-Ham)
(Central University of Punjab, 2018)Indian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antiproliferative activity. Dried powder of fruits of Piper attenuatum (Buch-Ham) was subjected to maceration to prepare various ... -
3-D QSAR Study Of Combretastatins Fused With Hetrocyclic Ring As Tubulin Binding Agents
(Central University of Punjab, 2018)Combretastatin A4 (CA4) is a leading agent in vascular disrupting strategies and tubulin polymerization inhibitor for the tumour therapy. A large number of combretastatin derivatives have been synthesized as potent ... -
Synthesis And Antiproliferative Activity Of Pyrazole-Based Heterocycles
(Central University of Punjab, 2018)Among the various heterocyclic compounds pyrazole and its derivatives have occupied wide range of biological and pharmacological activities. These were observed for their modes of function in the inhibition of topoisomerase ... -
Synthesis and in silico studies of pyrazoline containing quinoline derivatives as anti-HIV agents
(Central University of Punjab, 2018)Quinoline moiety is an important scaffold in the field of drug discovery and drug development with wide range of pharmacological activities. Its derivatives are potent inhibitors for reverse transcriptase which is responsible ...