Browsing Human Genetics and Molecular Medicine-Master Dissertation by Title
Now showing items 6-19 of 19
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Eeffect of Natural Compounds on Her2 Expression
(Central University of Punjab, 2018)Breast cancer is a heterogeneous disease that is challenging to treat.we examine potential natural compounds which may help in treating her2 positive breast cancer. The main objectives of this study are to determine the ... -
Evaluation Of Association Of Folic Acid Metabolism In Chronic Obstructive Pulmonary Disease
(Central University of Punjab, 2018)COPD is characterized by increasing breathlessness. It is the fourth cause of death in the world and it is currently presenting a major global public health challenge, causing premature death from pathophysiological ... -
Expression of CHAC1 in Breast Cancer Cell Lines
(Central University of Punjab, 2018)Breast cancer is the commonly diagnosed type of cancer in women and is a major cause of deaths in women. Unfolded Protein Response Pathway is a signaling pathway induced in endoplasmic reticulum as a stress response. This ... -
Expression of KIBRA in Breast Cancer Cell Lines
(Central University of Punjab, 2018)Breast cancer the most frequently diagnosed cancer and its metastasis to distant organs accounts the majority of deaths. Numerous genes and proteins are involved in the cause of metastasis. Though KIBRA is one of the ... -
Generation of Rho-0 Cells using MDA-MB-231 Cell Line and Measurement of Drug Cytotoxicity
(Central University of Punjab, 2018)The ATP generation via Oxidative phosphorylation (OXPHOS) system located in the inner membrane of mitochondria, is regulated by the coordinated interaction between nucleus and mitochondria. In the same context, ... -
Identification of Novel lncRNA in Breast Cancer Cell Line
(Central University of Punjab, 2018)Long non-coding RNA(lncRNA) is RNA transcript having size of more 200 nucleotides and low number of exons are present due to which it expressed at lower level in specific tissues. Mainly the lncRNA is involved in gene ... -
Identifying novel miRNA targets of anticancer drugs in normoxic and hypoxic condition
(Central University of Punjab, 2018)Breast cancer has become the prevailing cause of death, so the research for their treatment has become advanced day by day. Breast cancer behaves differently in normoxic and hypoxic condition so does the anticancer drugs ... -
In Silico Design Of Compounds As Sglt2 Inhibitors
(Central University of Punjab, 2018)SGLT2 inhibitors (SGLT2i) are the current novel therapeutic approach expected to control the growing threat of type 2 diabetes mellitus (T2DM). With comparatively least reported side effects, SGLT2i (gliflozins) have been ... -
Investigation for Maternal Uniparental Disomy of Chromosome 7 in a Silver Russell Syndrome patient
(Central University of Punjab, 2018)Silver-Russell syndrome (SRS) is a genetically heterogeneous disorder. Individuals with SRS show clinical features with varying severity. The major criteria for clinical diagnosis of SRS are intrauterine growth retardation ... -
Literature survey of HDACs in cancer and in-vitro analysis of HDAC inhibitor mediated chemo-sensitization
(Central University of Punjab, 2018)HDACs are chromatin modifying enzymes and post translational modifiers regulating transcription and activity of various proteins such as tubulin, Hsp90 and cortactin respectively. HDAC is divided into four classes (Class ... -
Meta-analysis and estimation of gene expression to establish the role of SFTPD in COPD
(Central University of Punjab, 2018)COPD is considered to be third leading cause of death by 2020. So far, there is no proper biomarker available for the diagnosis of all the different sub-phenotypes. Multiple GWAS studies have reported the role of SFTPD ... -
Potential Mitochondrial-Specific Function Of piRNAs
(Central University of Punjab, 2018)Piwi-interacting RNAs (piRNAs) are (26-31 nt) small noncoding RNAs processed from their longer precursor transcripts with the help of Piwi proteins. There are more than 30,000 piRNA genes present in the human genome which ... -
Psychological Burden Faced By Vitiligo Patients: A Comparative Study In Kerala And Punjab
(Central University of Punjab, 2018)Vitiligo is a common chronic skin disease having unknown aetiology, which causes a disfigurement and variable amount of skin and hair depigmentation and may affect a patient?s quality of life. To assess the psychological ... -
Study the effect of phytochemicals phenethyl isothiocyanate (PEITC) and Quercetin on mitochondrial biogenesis in cancer and normal cell lines
(Central University of Punjab, 2018)Phytochemicals are plant-derived chemicals generally are biologically active compounds and mediate positive health benefits by targeting genes or metabolic pathways of a cell. The phytochemicals examined can be classified ...