| dc.contributor.author | Kumari, Anjna | |
| dc.date.accessioned | 2018-08-31T04:13:38Z | |
| dc.date.available | 2018-08-31T04:13:38Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Kumari, Anjna (2018) Understanding Immune-etiology of Psoriasis: An autoimmune disease | en_US |
| dc.identifier.uri | http://kr.cup.edu.in/handle/32116/1818 | |
| dc.description.abstract | Psoriasis is a chronic inflammatory autoimmune disease. Disease etiology is understood in terms of altered crosstalk between skin keratinocytes and immune cell infiltrates, specifically T cells leading to the development of characteristic psoriatic skin lesions. T cell alterations in skin lesions as well as in the peripheral blood of psoriatic patients have been shown to be associated with the disease condition. With a major research focus on keratinocyte abnormalities, more studies are required to understand the immune-etiology of disease. There are fewer reports with inconsistence findings on T cell changes in psoriatic patients. Towards this end, we performed a study using blood samples from psoriasis patients and healthy controls to access alterations in peripheral blood mononuclear cell and T cell count along with phenotyping of blood cells in terms of CD4+ Th and CD8+ Tc cells and expression pattern of T cell-associated cytokines in plasma samples. Furthermore, TREC analysis was done to understand possible origin of T cell alterations associated with psoriasis. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Central University of Punjab | en_US |
| dc.subject | Autoimmune disease | en_US |
| dc.subject | Psoriasis | en_US |
| dc.subject | PBMCs | en_US |
| dc.subject | T cells | en_US |
| dc.subject | Cytokines | en_US |
| dc.subject | T Cell Receptor Excision Circles | en_US |
| dc.title | Understanding Immune-etiology of Psoriasis: An autoimmune disease | en_US |
| dc.type | Master Dissertation | en_US |
| dc.contributor.supervisor | Jain, Manju | |
| dc.identifier.accessionno | T00651 | |
