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dc.contributor.authorSingh G
dc.contributor.authorMishra, S
dc.contributor.authorChander, Harish
dc.date.accessioned2019-09-03T09:48:03Z
dc.date.available2019-09-03T09:48:03Z
dc.date.issued2019
dc.identifier.citationSingh G., Mishra, S.andChander, H.,KIBRA Team Up with Partners to Promote Breast Cancer Metastasis.10.1007/s12253-019-00660-xen_US
dc.identifier.issn12194956
dc.identifier.urihttp://210.212.34.21/handle/32116/2459
dc.description.abstractAmong women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized by many genetic aberrations including mutations, overexpression of oncogenes etc. KIBRA (KIdney/BRAin protein), a scaffolding protein is recently described as an important player in the process of invasion and metastasis. The Kidney/BRAin protein through its different domains interacts with various proteins to couple cytoskeleton arrangement, cell polarity and migration. N terminal and C terminal of the protein contains the WW, Internal C 2 & putative class III PDZ domain that interacts with DDR1, DLC1 & PKCζ. These protein-protein interactions equip the breast cancer cells to invade and metastasize. Here, we discuss a comprehensive knowledge about the KIBRA protein, its domains and the interacting partners involved in metastasis of breast cancer. © 2019, Arányi Lajos Foundation.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectBreast Canceren_US
dc.subjectDDR1en_US
dc.subjectDLC1 & PKCζen_US
dc.subjectKibraen_US
dc.subjectMetastasisen_US
dc.titleKIBRA Team Up with Partners to Promote Breast Cancer Metastasisen_US
dc.typeReviewen_US
dc.identifier.doi10.1007/s12253-019-00660-x
dc.identifier.urlhttps://link.springer.com/article/10.1007/s12253-019-00660-x
dc.title.journalPathology and Oncology Researchen_US
dc.type.accesstypeClose Accessen_US


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