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dc.contributor.authorChawda, N
dc.contributor.authorMishra, S
dc.contributor.authorBasu, M
dc.contributor.authorChander, H
dc.contributor.authorPodder, R
dc.contributor.authorMahapatra, S.K
dc.contributor.authorBanerjee, I.
dc.identifier.citationChawda, N; Mishra, S; Basu, M. et. Al. (2019) Synthesis of gadolinium oxide nanocuboids for in vitro bioimaging applications. Materials Research Express. Vol. 6(10).en_US
dc.description.abstractUndoped and Eu-doped gadolinium oxide (GGNCs and EGNCs) nanocuboids functionalized with D-gluconic acid (GA) were synthesised by a simple yet unique scheme using all the benign solvents and temperature. Samples were characterized and presented with properties like good dispersity, biocompatibility, and stability required for standard contrast agent used in magnetic resonance imaging (MRI) and optical coherence tomography (OCT). Biological assays such as 3-(4, 5-dimethyl-2-yl)-2, 5-diphenyltetrazoliumbromide (MTT) assay, flow cytometry and confocal microscopy were used to determine its biocompatibility, cellular internalization and optical cellular imaging using A549 and H1299 lung cancer cell lines. EGNCs treated with cell lines emitted red fluorescence which was used to track the internalization of EGNCs within the cells. GGNCs sample showed ?20% enhanced MRI relaxivity as compared to EGNCs; whereas EGNCs revealed better contrast in doctor scans of OCT. Samples could be used as promising candidate for other biomedical applications such as drug delivery when equipped with well functionalised drug molecules.en_US
dc.publisherInstitute of Physics Publishingen_US
dc.subjectGadolinium oxide nanocuboidesen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectOptical coherence tomographyen_US
dc.titleSynthesis of gadolinium oxide nanocuboids for in vitro bioimaging applicationsen_US
dc.title.journalMaterials Research Expressen_US
dc.type.accesstypeClosed Accessen_US

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