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Genetics of platelet traits in ischaemic stroke: focus on mean platelet volume and platelet count

dc.contributor.authorVasudeva K.
dc.contributor.authorMunshi A.
dc.date.accessioned2020-01-31T11:33:57Z
dc.date.available2020-01-31T11:33:57Z
dc.date.issued2019
dc.identifier.issn207454
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/2539
dc.description.abstractPurpose/Aim of the study: The aim of this review is to summarize the role of genetic variants affecting mean platelet volume (MPV) and platelet count (PLT) leading to higher platelet reactivity and in turn to thrombotic events like stroke and cardiovascular diseases. Materials and Methods: A search was conducted in PUBMED, MEDLINE, EMBASE, PROQUEST, Science Direct, Cochrane Library, and Google Scholar related to the studies focussing on genome-wide association studies (GWAS), whole exome sequencing (WES), whole genome sequencing (WGS), phenome-wide association studies (PheWAS) and multi-omic analysis that have been employed to identify the genetic variants influencing MPV and PLT. Results: Antiplatelet agents underscore the crucial role of platelets in the pathogenesis of stroke. Higher platelet reactivity in terms of mean platelet volume (MPV) and platelet count (PLT) contributes significantly to the interindividual variation in platelet reaction at the site of vessel wall injury. Some individuals encounter thrombotic events as platelets get occluded at the site of vessel wall injury whereas others heal the injury without occluding the circulation. Evidence suggests that MPV and PLT have a strong genetic component. High throughput techniques including genome-wide association studies (GWAS), whole exome sequencing (WES), whole genome sequencing (WGS), phenome-wide association studies (PheWAS) and multi-omic analysis have identified different genetic variants influencing MPV and PLT. Conclusions: Identification of complex genetic cross talks affecting PLT and MPV might help to develop novel treatment strategies in treating neurovascular diseases like stroke. � 2019, � 2018 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.subjectGWASen_US
dc.subjectMean platelet volumeen_US
dc.subjectplatelet counten_US
dc.subjectstrokeen_US
dc.titleGenetics of platelet traits in ischaemic stroke: focus on mean platelet volume and platelet counten_US
dc.typeReviewen_US
dc.identifier.doi10.1080/00207454.2018.1538991
dc.identifier.urlhttps://www.tandfonline.com/doi/abs/10.1080/00207454.2018.1538991?journalCode=ines20
dc.title.journalInternational Journal of Neuroscienceen_US
dc.type.accesstypeClose Accessen_US


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