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dc.contributor.authorSharma P.
dc.contributor.authorBharat
dc.contributor.authorDogra N.
dc.contributor.authorSingh S.
dc.date.accessioned2020-01-31T11:34:01Z
dc.date.available2020-01-31T11:34:01Z
dc.date.issued2019
dc.identifier.issn15665240
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/2573
dc.description.abstractMicroRNAs [miRNAs] are short, non-coding, single stranded RNA molecules regulating gene expression of their targets at the posttranscriptional level by either degrading mRNA or by inhibiting translation. Previously, miRNAs have been reported to be present inside the mitochondria and these miRNAs have been termed as mito-miRs. Origin of these mito-miRs may either be from mitochondrial genome or import from nucleus. The second class of mito-miRs makes it important to unravel the involvement of miRNAs in crosstalk between nucleus and mitochondria. Since miRNAs are involved in various physiological processes, their deregulation is often associated with disease progression, including cancer. The current review focuses on the involvement of miRNAs in different mitochondrial mediated processes. It also highlights the importance of exploring the interaction of miRNAs with mitochondrial genome, which may lead to the development of small regulatory RNA based therapeutic options.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.subjectCanceren_US
dc.subjectChemoresistanceen_US
dc.subjectMetabolismen_US
dc.subjectmiRNAsen_US
dc.subjectMitochondriaen_US
dc.subjectNanoparticlesen_US
dc.titleSmall regulatory molecules acting big in cancer: Potential role of mito-miRs in canceren_US
dc.typeReviewen_US
dc.identifier.doi10.2174/1566524019666190723165357
dc.identifier.urlhttp://www.eurekaselect.com/173784/article
dc.title.journalCurrent Molecular Medicineen_US
dc.type.accesstypeClose Accessen_US


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