Show simple item record

1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway

dc.contributor.authorAlex, Jimi M.
dc.contributor.authorSingh, Sandeep
dc.contributor.authorKumar, Raj
dc.date.accessioned2017-08-03T09:19:13Z
dc.date.available2017-08-03T09:19:13Z
dc.date.issued2014
dc.date.issued2014
dc.identifier.citationAlex, J. M., Singh, S., & Kumar, R. (2014). 1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway. Archiv Der Pharmazie, 347(10), 717-727. doi: 10.1002/ardp.201400199en_US
dc.identifier.issnPrint- 0365-6233
dc.identifier.issnOnline- 1521-4184
dc.identifier.issn3656233
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/279
dc.description.abstractA series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative potential against breast cancer (MCF-7 and T-47D) and lung cancer (H-460 and A-549) cell lines for the first time. JP-1-7, -10, -11, -14, and -15 were observed to exhibit significant anti-proliferative activity against MCF-7 cells. Some notions about structure-activity relationships are reported. The investigated compounds were found to lower the intracellular reactive oxygen species in the H2DCFDA assay and also caused mitochondria-dependent cell death in the MCF-7 cell line, indicating a plausible mechanism of their anticancer effect. Analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1-17) were synthesized and evaluated for their anti-proliferative activity in four cancer cell lines and for their intracellular ROS scavenging properties. An attempt was made to determine the mitochondrial membrane potential of MCF-7 cells treated with JP-1 and -14, aiming to elucidate the mechanism by which proliferation was curbed. ? 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.language.isoenen_US
dc.publisherWiley-VCH Verlagen_US
dc.subject1 acetyl 3,5 diaryl 4,5 dihydro(1h)pyrazole derivativeen_US
dc.subject1 [3 (2,4 dichlorophenyl) 5 (furan 2 yl) 4,5 dihydro(1h)pyrazol 1 yl]ethanoneen_US
dc.subject1 [3 (2,4 dichlorophenyl) 5 (thiophen 2 yl) 4,5 dihydro(1h)pyrazol 1 yl]ethanoneen_US
dc.subject1 [3 (4 bromophenyl) 5 (furan 2 yl) 4,5 dihydro(1h)pyrazol 1 yl]ethanoneen_US
dc.subject1 [3 (4 bromophenyl) 5 (thiophen 2 yl) 4,5 dihydro(1h)pyrazol 1 yl]ethanoneen_US
dc.subject1 [3 (4 chlorophenyl) 5 (furan 2 yl) 4,5 dihydro(1h)pyrazol 1 yl]ethanoneen_US
dc.subject1 [3 (4 chlorophenyl) 5 (thiophen 2 yl) 4,5 dihydro(1h)pyen_US
dc.title1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathwayen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/ardp.201400199
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.201400199
dc.title.journalArchiv der Pharmazie


Files in this item

Thumbnail
Name:
7.pdf
Size:
539.0Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record