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dc.contributor.authorMukherjee, Soumi
dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorChhabra, Ravindresh
dc.contributor.authorReddy, P. Hemachandra
dc.contributor.authorBhatti, Jasvinder Singh
dc.date.accessioned2024-01-16T14:23:22Z
dc.date.available2024-01-16T14:23:22Z
dc.date.issued2023-02-09T00:00:00
dc.identifier.issn7533322
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2023.114398
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/2918
dc.description.abstractThe importance of mitochondria is not only limited to energy generation but also in several physical and chemical processes critical for cell survival. Mitochondria play an essential role in cellular apoptosis, calcium ion transport and cellular metabolism. Mutation in the nuclear and mitochondrial genes, altered oncogenes/tumor suppressor genes, and deregulated signalling for cell viability are major reasons for cancer progression and chemoresistance. The development of drug resistance in cancer patients is a major challenge in cancer treatment as the resistant cells are often more aggressive. The drug resistant cells of numerous cancer types exhibit the deregulation of mitochondrial function. The increased biogenesis of mitochondria and its dynamic alteration contribute to developing resistance. Further, a small subpopulation of cancer stem cells in the heterogeneous tumor is primarily responsible for chemoresistance and has an attribute of mitochondrial dysfunction. This review highlights the critical role of mitochondrial dysfunction in chemoresistance in cancer cells through the processes of apoptosis, autophagy/mitophagy, and cancer stemness. Mitochondria-targeted therapeutic strategies might help reduce cancer progression and chemoresistance induced by various cancer drugs. � 2023en_US
dc.language.isoen_USen_US
dc.publisherElsevier Masson s.r.l.en_US
dc.subjectApoptosis, Autophagyen_US
dc.subjectCancer chemoresistanceen_US
dc.subjectMitochondrial biogenesis, Stemnessen_US
dc.subjectMitochondrial dynamicsen_US
dc.subjectMitochondrial dysfunctionen_US
dc.titleTargeting mitochondria as a potential therapeutic strategy against chemoresistance in canceren_US
dc.typeReviewen_US
dc.identifier.doi10.1016/j.biopha.2023.114398
dc.title.journalBiomedicine and Pharmacotherapyen_US
dc.type.accesstypeOpen Accessen_US


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