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dc.contributor.authorRanga, Shalu
dc.contributor.authorYadav, Ritu
dc.contributor.authorChhabra, Ravindresh
dc.contributor.authorChauhan, Meenakshi B.
dc.contributor.authorTanwar, Mukesh
dc.contributor.authorYadav, Chetna
dc.contributor.authorKadian, Lokesh
dc.contributor.authorAhuja, Parul
dc.date.accessioned2024-01-16T14:23:23Z
dc.date.available2024-01-16T14:23:23Z
dc.date.issued2023-04-25T00:00:00
dc.identifier.issn13608185
dc.identifier.urihttps://doi.org/10.1007/s10495-023-01840-6
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/2923
dc.description.abstractCervical cancer is among the leading causes of cancer-associated mortality in women. In spite of vaccine availability, improved screening procedures, and chemoradiation therapy, cervical cancer remains the most commonly diagnosed cancer in 23 countries and the leading cause of cancer deaths in 36 countries. There is, therefore, a need to come up with novel diagnostic and therapeutic targets. Long non-coding RNAs (lncRNAs) play a remarkable role in genome regulation and contribute significantly to several developmental and disease pathways. The deregulation of lncRNAs is often observed in cancer patients, where they are shown to affect multiple cellular processes, including cell cycle, apoptosis, angiogenesis, and invasion. Many lncRNAs are found to be involved in the pathogenesis as well as progression of cervical cancer and have shown potency to track metastatic events. This review provides an overview of lncRNA mediated regulation of cervical carcinogenesis and highlights their potential as diagnostic and prognostic biomarkers as well as therapeutic targets for cervical cancer. In addition, it also discusses the challenges associated with the clinical implication of lncRNAs in cervical cancer. � 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectCervical canceren_US
dc.subjectClinical biomarkersen_US
dc.subjectlncRNAsen_US
dc.subjectPathogenesisen_US
dc.subjectTherapeutic targetsen_US
dc.titleLong non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectivesen_US
dc.typeReviewen_US
dc.identifier.doi10.1007/s10495-023-01840-6
dc.title.journalApoptosisen_US
dc.type.accesstypeOpen Accessen_US


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