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dc.contributor.authorAlex, Jimi Marin
dc.contributor.authorKumar, Raj
dc.date.accessioned2017-08-08T07:23:16Z
dc.date.available2017-08-08T07:23:16Z
dc.date.issued2014
dc.identifier.citationAlex, J. M., & Kumar, R. (2014). 4,5-Dihydro-1H-pyrazole: An indispensable scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry, 29(3), 427-442. doi: 10.3109/14756366.2013.795956en_US
dc.identifier.issn14756366
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/299
dc.description.abstractPyrazoles, categorized as nitrogen-containing heterocycles, are well known for their interminable participation in the field of perpetual research and development of therapeutical active agents. As a consequence pyrazoles became an inevitable core of numerous drugs having diverse activities. The broad spectrum of activities portrayed by the pyrazoles instigated the researchers to modify the pyrazole ring as 4,5-dihydro-1H-pyrazoles commonly known as 2-pyrazolines. The present review is a concerted effort to retrace compounds covered from 2009-till date which owe diverse biological activities to the 2-pyrazoline scaffold and also condenses the retro-synthetic approaches employed for their synthesis. This endeavor culminated in revelation that inhibitory potential varied when the substituents in particular N-substituents of 2-pyrazolines were altered. ? 2014 Informa UK Ltd.en_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.subject4,5 dihydro 1h pyrazoleen_US
dc.subjectBiological Activitiesen_US
dc.subjectSynthesisen_US
dc.title4,5-Dihydro-1H-pyrazole: An indispensable scaffolden_US
dc.typeReviewen_US
dc.identifier.doi10.3109/14756366.2013.795956
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.3109/14756366.2013.795956
dc.title.journalJournal of Enzyme Inhibition and Medicinal Chemistry


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