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Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
(Association of Pharmaceutical Teachers of India, 2018)
Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ...
Thickness-dependent magnetic and transport properties of La0.5Sr0.5MnO3 thin films deposited by DC magnetron sputtering on the LaAlO3 substrate
(Springer Verlag, 2018)
Thickness-dependent structural, magnetic and transport properties of La0.5Sr0.5MnO3 (LSMO) thin films have been studied. A series of the LSMO films with thickness 30, 60, 125 and 300?nm have been deposited on the LaAlO3 ...
Recent synthetic strategies for monocyclic azole nucleus and its role in drug discovery and development
(Bentham Science Publishers B.V., 2018)
Background: In recent years, the development and diversification of heterocyclic compounds has become central to the discovery of bioactive compounds with novel or improved pharmacological properties. In particular, ...
Effect of lattice defects on the structural and optical properties of Ni1 − XAgXO (where X = 0.0, 0.01, 0.03, 0.05, 0.10 and 0.15) nanoparticles
(Springer, 2018)
The Ni1 − XAgXO (where X = 0, 0.01, 0.02, 0.03, 0.05, 0.10, and 0.15) nanoparticles are synthesized by sol–gel technique. The effects of Ag-doping in NiO nanoparticle on the structural and optical properties are studied. ...
Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors
(Academic Press Inc., 2018)
Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of ...
Four-dimensional conformally flat Berwald and Landsberg spaces
(Informatics Publishing Limited and The Indian Mathematical Society, 2018)
The problem of conformal transformation and conformal atness of Finsler spaces has been studied in [6], [16], [17], [20], [21]. Recently, Prasad et. al [19] have studied three dimensional conformally at Landsberg and Berwald ...
Alloyed monolayers of Cu, Ag, Au and Pt in hexagonal phase: A comprehensive first principles study
(Elsevier Ltd, 2018)
We present density functional theory (DFT) based comprehensive study of two-dimensional (2D) alloyed monolayers of noble metals (AgCu, AgPt, AgAu, AuCu, AuPt and CuPt) in hexagonal phase within numerical atomic orbitals ...
Ganoderic acid, lanostanoid triterpene: a key player in apoptosis
(Springer New York LLC, 2018)
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell ...
Structural, Morphological, Thermal, and Pasting Properties of Starches From Diverse Indian Potato Cultivars
(Wiley-VCH Verlag, 2018)
Starches from 42 diverse Indian potato cultivars are evaluated for diversity in structural (amylose content and amylopectin chain length distribution), morphological (granules size distribution), thermal, and pasting ...
miR-301, pleiotropic MicroRnA in Regulation of inflammatory Bowel Disease and ColitisAssociated Cancer
(Frontiers in Immunology, 2018)
Inflammatory bowel disease (IBD) is a chronic idiopathic, relapsing, and remitting immune disorders of gastrointestinal tract which consist of two forms, i.e., Crohn’s disease (affect the whole gastrointestinal tract) and ...