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The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer
(Impact Journals LLC, 2017)
Chemoresistance is one of the major hurdles in the treatment of breast cancer, which limits the effect of both targeted and conventional therapies in clinical settings. Therefore, understanding the mechanisms underpinning ...
Heck−Suzuki Tandem Reaction for the Synthesis of 3‑Benzazepines
(ACS Publications, 2015)
A novel procedure for the Heck−Suzuki tandem reaction suitable for the construction of nitrogen-containing medium rings was developed to provide access toward the 3-benzazepine framework.
Painlevé analysis and invariant solutions of Vakhnenko–Parkes (VP) equation with power law nonlinearity
(Springer, 2016)
The Vakhnenko–Parkes (VP) equation with
power law nonlinearity is analyzed for Painlevé test
and for Lie symmetries. The Painlevé analysis of
Vakhnenko–Parkes equation with power law nonlin-
earity is performed by the ...
Genetic and epigenetic markers in colorectal cancer screening: recent advances
(Taylor & Francis, 2017)
Introduction: Colorectal cancer (CRC) is a heterogenous disease which develops from benign intraepithelial lesions known as adenomas to malignant carcinomas. Acquired alterations in Wnt signaling, TGFβ, MAPK pathway genes ...
Mechanisms of tubulin binding ligands to target cancer cells: Updates on their therapeutic potential and clinical trials
(Bentham Science Publishers B.V., 2017)
Background: A number of chemically diverse substances bind to the tubulin and inhibit cell proliferation by disrupting microtubule dynamics. There are four binding sites for the ligands binding to the tubulin; taxane/epothilone ...
Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
(Association of Pharmaceutical Teachers of India, 2018)
Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ...
Proteomics provides insights into biological pathways altered by plant growth promoting bacteria and arbuscular mycorrhiza in sorghum grown in marginal soil
(Elsevier B.V., 2017)
Sorghum is an economically important crop, a model system for gene discovery and a biofuel source. Sorghum seedlings were subjected to three microbial treatments, plant growth promoting bacteria (B), arbuscular mycorrhizal ...
3-Cyano-2-azaanthracene-based ‘‘push-pull” fluorophores: A one-step preparation from 5-cyano-1,2,4-triazines and 2,3-dehydronaphthalene, generated in situ
(Elsevier, 2016)
A facile one-step approach towards 3-cyano-2-azaanthracenes via the [4+2] cycloaddition reaction between 5-cyano-1,2,4-triazines and 2,3-dehydronaphthalene, generated in situ from commercially available 3-amino-2-naphthoic ...
Invariant solutions of Biswas-Milovic equation
(Springer Netherlands, 2017)
The Biswas-Milovic equation in generalized form and with power law nonlinearity is analyzed for Lie symmetries. The classical Lie group method is applied to derive symmetries of this equation, and the ordinary differential ...
Role of Macromolecular Crowding on Stability and Iron Release Kinetics of Serum Transferrin
(American Chemical Society, 2017)
The macromolecular crowding influences the structural stability and functional properties of transferrin (Tf). The equilibrium as well as kinetic studies of Tf at different concentrations of crowding agents (dextran 40, ...