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Ganoderic acid modulating TNF and its receptors: in silico and in vitro study
(Springer, 2017)
Cancer is a multifactorial disease with a network of genes causing genetic alterations. The sophisticated techniques in molecular biology revealed different cancer pathway, but their mechanistic approach is still shrouded. ...
Triterpenes in cancer: significance and their influence
(Springer Netherlands, 2016)
Natural products are enriched with numerous compounds with a broad spectrum of therapeutics indication suggesting the role of functional moieties as a core pharmacophore. This review highlights the role of triterpene in ...
Differential algorithms-assisted molecular modeling-based identification of mechanistic binding of ganoderic acids
(Springer, 2015)
Ganoderma, in the recent years, has been comprehensively characterized and held invaluable for their miscellaneous pharmacological activities. Recently, attempts to explore and fathom the pathway of inhibition revealed ...
Alternate mild drought stress (20.1 MPa PEG) immunizes sensitive chickpea cultivar against lethal chilling by accentuating the defense mechanisms
(Springer, 2016)
The changes in climate particularly, the rise in temperature and humidity affect the physiological functions of plants subsequently affecting crop productivity adversely. A strategy is required which can be directly ...
Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study
(Springer Netherlands, 2016)
Receptor tyrosine kinases (RTKs) are transmembrane high-affinity surface receptors responsible for cell migration, adhesion, apoptosis, metabolism, and cell proliferation activities in various cancers. Minute aberration ...
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity
(2013)
Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar ...
Amino acid functionalized zinc oxide nanostructures for cytotoxicity effect and hemolytic behavior: Theoretical and experimental studies
(Elsevier Ltd, 2017)
Blending of theoretical and experimental approach, provide an important strategy in designing the nanostructure at a microscopic level and helps in predicting the response of synthesized material towards inhibition of the ...
Ganoderic Acid A Targeting ?-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study
(Springer Berlin Heidelberg, 2018)
Wnt signaling pathways are the group of signaling transduction controlling the embryonic development, cell proliferation, cell migration, cell fate specification, and body axis pattern. Nuclear accumulation of ?-catenin ...
Identifying the preferred interaction mode of naringin with gold nanoparticles through experimental, DFT and TDDFT techniques: Insights into their sensing and biological applications
(Royal Society of Chemistry, 2016)
In this work, the binding behaviour of naringin-a flavonoid with AuNPs is explained by combining experimental and theoretical approaches. We have systematically analysed the effect of temperature and concentration of ...
Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)
(Springer, 2018)
Purpose
Despite a growing body of evidence indicating a potential efficacy of the anti-diabetic metformin as anti-cancer agent, the exact mechanism underlying this efficacy has remained largely unknown. Here, we aimed at ...