Iodine-Catalysed Synthesis of ?-Carboline Tethered ?-Amino Amidines Through Ugi-Type Multicomponent Reaction
Date
2022-09-15Author
Singh, Manpreet
Vaishali
Jamra, Rahul
Deepika
Kumar, Sunit
Singh, Virender
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A simple and efficient iodine catalysed protocol has been unfolded for the synthesis of novel ?-carboline C1-linked ?-amino amidines via one-pot assembly of 1-formyl ?-carbolines (Kumujian C analogues), anilines and isocyanides. This domino strategy proceeds through the formation of three C?N bonds in a single operation. The advantageous features of the developed methodology include one-pot synthesis, operational simplicity, high atom economy, broad substrate scope, multicomponent character, easy purification procedure (no column chromatography) and applicability towards gram scale synthesis. The scope of strategy has been demonstrated with the construction of a library of 32 novel ?-carboline tethered ?-amino amidines having three points of diversity. � 2022 Wiley-VCH GmbH.
Journal
ChemistrySelect
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Closed Access