A cascade A3 coupling strategy towards the regioselective synthesis of ?-carboline N-fused pyrrole derivatives with pyridine tethers
Date
2022-12-01Author
Vaishali, None
Malakar, Chandi C.
Singh, Virender
Metadata
Show full item recordAbstract
A potential three component reaction strategy has been devised to generate nature inspired ?-carboline N-fused pyrroles containing pyridine tethers. These scaffolds were afforded in high yields via a one-pot cascade regioselective reaction of diverse Kumujian C, 2-aminopyridines and alkyne derivatives under Cu(ii)-catalysis. A library of 32 novel indolizino[8,7-b]indole derivatives with pyridine tethers has been developed. The current protocol offers excellent regioselectivity, high atom-economy and significant structural diversity. � 2023 The Royal Society of Chemistry.
Journal
New Journal of Chemistry
Access Type
Closed Access
Collections
Related items
Showing items related by title, author, creator and subject.
-
Copper catalysed regioselective synthesis of pyrimidine substituted Indolizino[8,7-b]indole derivatives via cascade A3 annulation
Kumar, Sunit; Kumar, Rakesh; Malakar, Chandi C.; Singh, Virender (Elsevier Ltd, 2023-07-08)Cu(II) salt has been found to be an efficient catalyst for the regioselective synthesis of a series of novel indolizino [8,7-b]indole derivatives with pyrimidine tethers via three-component annulation of 1-formyl-9H-?-carbolines ... -
Acetyl oxime/azirine 1, 3-dipole and strategy for the regioselective synthesis of polysubstituted pyrroles via [3 + 2] cycloaddition with alkyne utilizing Fe2O3@cellulose catalyst
Dwivedi, Kartikey Dhar; Kumar, Bhupender; Reddy, Marri Sameer; Borah, Biplob; Nagendra Babu, J.; Chowhan, L. Raju (Elsevier B.V., 2021-09-27)Fe2O3@cellulose catalyzed regioselective [3 + 2] cycloaddition of acetyl oxime with alkynes via 2H?azirines intermediate generated in situ in an aqueous ethanolic medium is described. The methodology is highly regioselective ... -
Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors
Kumar, Bhupinder; Sheetal; Mantha, Anil K.; Kumar, Vinod (Academic Press Inc., 2018)Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of ...