An efficient metal-free and catalyst-free C�S/C�O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides
Date
2023-03-02Author
Sharma, Shubham
Singh, Dharmender
Kumar, Sunit
Vaishali
Jamra, Rahul
Banyal, Naveen
Deepika
Malakar, Chandi C.
Singh, Virender
Metadata
Show full item recordAbstract
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. The advantages of this developed protocol refer to the broad substrate scope, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5-linked amide conjugates were also synthesized via an oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant. � 2023 Sharma et al.
Journal
Beilstein Journal of Organic Chemistry
Access Type
Open Access