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    Understanding the multifaceted role of ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) and its altered behaviour in human diseases

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    Date
    2015
    2015
    Author
    Cholia, R.P.
    Nayyar, H.
    Kumar, R.
    Mantha, Anil K.
    Metadata
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    Abstract
    Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). LPA is the bioactive product of ENPP2 enzyme, which induces diverse signalling pathways via six LPA-G-protein coupled receptors (GPCRs). ENPP2 is an essential protein for normal development and its altered expression is associated with various human diseases. Cellular ENPP2 silencing results in lethality at the embryonic stage in mice. Initially, it is identified as an autocrine factor in melanoma cells. Different research groups are currently exploring to understand the multifaceted role of ENPP2 in various processes such as embryonic and neural development, migration, invasion, differentiation, proliferation, angiogenesis, and survival. Altered expression of ENPP2 is also associated with various diseases like inflammation, cancer, fibrosis, rheumatoid arthritis and neural defects. In this article, we have summarized structural aspects of ENPP2 and biochemical functions associated with its diverse cellular roles in various human diseases including cancer and Alzheimer's disease (AD). In addition, keeping in view and advocating findings, a note on various phytochemicals and synthetic inhibitors, which are currently explored as therapeutic agents targeting functions of ENPP2 for the treatment of various human diseases is also presented. ? 2015 Bentham Science Publishers.
    Journal
    Current Molecular Medicine
    URI
    http://210.212.34.21/handle/32116/368
    URL
    http://www.eurekaselect.com/135095/article
    DOI
    10.2174/1566524015666150921104804
    Collections
    • Animal Sciences-Research Publications [78]
    • Pharmaceutical Sciences and Natural Products-Research Publications [135]

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    Initiatives by University Library 
    Central University of Punjab