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    Essential oils and their constituents as anticancer agents: A mechanistic view

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    Date
    2014
    Author
    Gautam, Nandini
    Mantha, Anil K.
    Mittal, Sunil
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    Abstract
    Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitro and in vivo studies for EOs and their constituents. This review also highlights in-depth various mechanisms of action of different EOs and their constituents reported in the treatment strategies for different types of cancer. The current review indicates that EOs and their constituents act by multiple pathways and mechanisms involving apoptosis, cell cycle arrest, antimetastatic and antiangiogenic, increased levels of reactive oxygen and nitrogen species (ROS/RNS), DNA repair modulation, and others to demonstrate their antiproliferative activity in the cancer cell. The effect of EOs and their constituents on tumour suppressor proteins (p53 and Akt), transcription factors (NF-B and AP-1), MAPK-pathway, and detoxification enzymes like SOD, catalase, glutathione peroxidase, and glutathione reductase has also been discussed. ? 2014 Nandini Gautam et al.
    Journal
    BioMed Research International
    Access Type
    Open Access
    URI
    http://210.212.34.21/handle/32116/371
    URL
    https://www.hindawi.com/journals/bmri/2014/154106/
    DOI
    10.1155/2014/154106
    Collections
    • Animal Sciences-Research Publications [78]
    • Environmental Science and Technology-Research Publications [168]

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    Initiatives by University Library 
    Central University of Punjab