Show simple item record

A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases

dc.contributor.authorMantha, Anil K.
dc.contributor.authorSarkar, Bibekananda
dc.contributor.authorTell, Gianluca
dc.date.accessioned2013-01-11T15:05:09Z
dc.date.available2013-01-11T15:05:09Z
dc.date.issued2014
dc.identifier.citationMantha, A. K., Sarkar, B., & Tell, G. (2014). A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases. Mitochondrion, 16, 38-49. doi: 10.1016/j.mito.2013.10.007en_US
dc.identifier.issn15677249
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/383
dc.description.abstractOxidative DNA damage results from the attack by reactive oxygen and nitrogen species (ROS/RNS) on human genome. This includes base modifications such as oxidized bases, abasic (AP) sites, and single-strand breaks (SSBs), all of which are repaired by the base excision repair (BER) pathway, one among the six known repair pathways. BER-pathway in mammalian cells involves several evolutionarily conserved proteins and is also linked to genome replication and transcription. The BER-pathway enzymes, namely, DNA glycosylases (DGs) and the end-processing proteins such as abasic endonuclease (APE1), form complexes with downstream repair enzymes via protein-protein and DNA-protein interactions. An emerging concept for BER proteins is their involvement in non-canonical functions associated to RNA metabolism, which is opening new interesting perspectives. Various mechanisms that are underlined in maintaining neuronal cell genome integrity are identified, but are inconclusive in providing protection against oxidative damage in neurodegenerative disorders, main emphasis is given towards the role played by the proteins of BER-pathway that is discussed. In addition, mechanisms of action of BER-pathway in nuclear vs. mitochondria as well as the non-canonical functions are discussed in connection to human neurodegenerative diseases. ? 2013 ? Elsevier B.V. and Mitochondria Research Society. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectDNA (apurinic or apyrimidinic site) lyaseen_US
dc.subjectDNA glycosyltransferaseen_US
dc.subjectDNA polymeraseen_US
dc.subjectEndonucleaseen_US
dc.subjectFlap endonucleaseen_US
dc.subjectMitochondrial proteinen_US
dc.subjectNuclear proteinen_US
dc.subjectPhosphodiesterase Ien_US
dc.subjectProtein DNA2en_US
dc.subjectProtein EXOGen_US
dc.subjectRNAen_US
dc.subjectUnclassified drugen_US
dc.subjectXRCC1 proteinen_US
dc.subjectDNAen_US
dc.subjectProtein bindingen_US
dc.subjectReactive nitrogen speciesen_US
dc.subjectReactive oxygen metabolite;en_US
dc.titleA short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseasesen_US
dc.typeReviewen_US
dc.identifier.doi10.1016/j.mito.2013.10.007
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1567724913002729?via%3Dihub
dc.title.journalMitochondrion


Files in this item

Thumbnail
Name:
16.pdf
Size:
957.6Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record