| dc.contributor.author | Kumar, Bhupinder | |
| dc.contributor.author | Sheetal | |
| dc.contributor.author | Mantha, Anil K. | |
| dc.contributor.author | Kumar, Vinod | |
| dc.date.accessioned | 2018-03-07T06:52:46Z | |
| dc.date.available | 2018-03-07T06:52:46Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Kumar, B., Sheetal, Mantha, A. K., & Kumar, V. (2018). Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors. Bioorganic Chemistry, 77, 252-262. doi: 10.1016/j.bioorg.2018.01.020 | en_US |
| dc.identifier.issn | 452068 | |
| dc.identifier.uri | http://kr.cup.edu.in/handle/32116/625 | |
| dc.description.abstract | Monoamine oxidase inhibitors (MAOIs) are potential drug candidates for the treatment of various neurological disorders like Parkinson's disease, Alzheimer's disease and depression. In the present study, two series of 4-substituted phenylpiperazine and 1-benzhydrylpiperazine (1?21) derivatives were synthesized and screened for their MAO-A and MAO-B inhibitory activity using Amplex Red assay. Most of the synthesized compounds were found selective for MAO-B isoform except compounds 3, 7, 8, 9 and 13 (MAO-A selective) while compound 11 was non-selective. In the current series, compound 12 showed most potent MAO-B inhibitor activity with IC50 value of 80 nM and compound 7 was found to be most potent MAO-A inhibitor with IC50 value of 120 nM and both the compounds were found reversible inhibitors. Compound 8 was found most selective MAO-A inhibitor while compound 20 was found most selective inhibitor for MAO-B isoform. In the cytotoxicity evaluation, all the compounds were found non-toxic to SH-SY5Y and IMR-32 cells at 25 ?M concentration. In the ROS studies, compound 8 (MAO-A inhibitor) reduced the ROS level by 51.2% while compound 13 reduced the ROS level by 61.81%. In the molecular dynamic simulation studies for 30 ns, compound 12 was found quite stable in the active cavity of MAO-B. Thus, it can be concluded that phenyl- and 1-benzhydrylpiperazine derivatives are promising MAO inhibitors and can act as a lead to design potent, and selective MAO inhibitors for the treatment of various neurological disorders. ? 2018 Elsevier Inc. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Academic Press Inc. | en_US |
| dc.subject | (4 benzhydrylpiperazin 1 yl)(4 nitrophenyl)methanone | en_US |
| dc.subject | (4 benzhydrylpiperazin 1 yl)(phenyl)methanone | en_US |
| dc.subject | (4 methoxyphenyl)(4 phenylpiperazin 1 yl)methanone | en_US |
| dc.subject | (4 methylpiperazin 1 yl)(4 tolyl)methanone | en_US |
| dc.subject | 1 (anthracen 9 yl) 4 benzhydrylpiperazine | en_US |
| dc.subject | 1 (naphthalen 1 yl) 4 phenylpiperazine | en_US |
| dc.subject | 1 benzhydryl 4 (naphthalen 1 yl)piperazine | en_US |
| dc.subject | 1 benzhydryl 4 benzylpiperazine | en_US |
| dc.subject | 1 benzhydryl 4 phenylpiperazine | en_US |
| dc.subject | 1 benzhydryl 4 tosylpiperazine | en_US |
| dc.subject | 1 benzhydryl 4 [(2 nitrophenyl)sulfonyl]piperazine | en_US |
| dc.subject | 1 benzhydryl 4 [(4 chloro | en_US |
| dc.title | Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1016/j.bioorg.2018.01.020 | |
| dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0045206817307782 | |
| dc.title.journal | Bioorganic Chemistry | |
